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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JSG</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Serious Games</journal-id>
      <journal-title>JMIR Serious Games</journal-title>
      <issn pub-type="epub">2291-9279</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v11i1e45539</article-id>
      <article-id pub-id-type="pmid">37801360</article-id>
      <article-id pub-id-type="doi">10.2196/45539</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Application of Fully Immersive Virtual Reality on Reminiscence Interventions for Older Adults: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Leung</surname>
            <given-names>Tiffany</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Dhikav</surname>
            <given-names>Vikas</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Craven</surname>
            <given-names>Michael</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Hopper</surname>
            <given-names>Louise</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Lu</surname>
            <given-names>Zhipeng</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Architecture, Texas A&#38;M University</institution>
            <addr-line>3137 TAMU</addr-line>
            <addr-line>College Station, TX, 77845</addr-line>
            <country>United States</country>
            <phone>1 9798456183</phone>
            <email>luzhipeng@live.com</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5558-0362</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>Wenjin</given-names>
          </name>
          <degrees>MDes</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2694-2456</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Yan</surname>
            <given-names>Wei</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1092-2474</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Kew</surname>
            <given-names>Chung Lin</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1720-4459</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Seo</surname>
            <given-names>Jinsil Hwaryoung</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0410-7203</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Ory</surname>
            <given-names>Marcia</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8036-2383</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Architecture, Texas A&#38;M University</institution>
        <addr-line>College Station, TX</addr-line>
        <country>United States</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>School of Public Health, Texas A&#38;M University</institution>
        <addr-line>College Station, TX</addr-line>
        <country>United States</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>School of Performance, Visualization &#38; Fine Arts, Texas A&#38;M University</institution>
        <addr-line>College Station, TX</addr-line>
        <country>United States</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Zhipeng Lu <email>luzhipeng@live.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>6</day>
        <month>10</month>
        <year>2023</year>
      </pub-date>
      <volume>11</volume>
      <elocation-id>e45539</elocation-id>
      <history>
        <date date-type="received">
          <day>5</day>
          <month>1</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>17</day>
          <month>5</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>15</day>
          <month>8</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>23</day>
          <month>8</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Zhipeng Lu, Wenjin Wang, Wei Yan, Chung Lin Kew, Jinsil Hwaryoung Seo, Marcia Ory. Originally published in JMIR Serious Games (https://games.jmir.org), 06.10.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Serious Games, is properly cited. The complete bibliographic information, a link to the original publication on https://games.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://games.jmir.org/2023/1/e45539" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The increasing number of older adults with mental, behavioral, and memory challenges presents significant public health concerns. Reminiscence is one type of nonpharmacological intervention that can effectively evoke memories, stimulate mental activities, and improve psychological well-being in older adults through a series of discussions on previous experiences. Fully immersive virtual reality (FIVR) may be a useful tool for reminiscence interventions because it uses realistic virtual environments connected to a person’s significant past stories.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This review aims to examine empirical evidence regarding the application of FIVR in reminiscence interventions, its usability and acceptability, and its effectiveness in assisting the intervention to achieve optimal outcomes.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) approach for scoping reviews. The PubMed, PsycINFO, Embase, CINAHL, Web of Science, ACM, and IEEE Xplore electronic databases were used for the search. We included peer-reviewed studies that used FIVR as an assistive tool for reminiscence interventions; were published between January 1, 2000, and August 1, 2022; reported empirical research; involved older adults as participants; and addressed health- and behavior-related outcomes or the feasibility and usability of FIVR. We used Endnote X9 to organize the search results and Microsoft Excel for data extraction and synthesis.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Of the 806 articles collected from the databases and other resources, 11 were identified. Most of the studies involved participants aged between 70 and 90 years. Only 1 study did not involve those with cognitive impairments, whereas 3 specifically targeted people living with dementia. The results indicated that FIVR reminiscence interventions enhanced engagement and reduced fatigue. Although some studies have observed positive effects on anxiety, apathy, depression, cognitive functions, and caregiver burden reduction, these findings were inconsistent across other research. In addition, FIVR showed overall usability and acceptability with manageable side effects among older adults across various health conditions during reminiscence sessions. However, 1 study reported adverse feelings among participants, triggered by unpleasant memories evoked by the virtual reality content.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The role of FIVR in reminiscence interventions remains nascent, with limited studies evaluating its impacts on older adults. Many of the reviewed studies had notable limitations: small sample sizes, absence of rigorous research design, limited assessment of long-term effects, lack of measures for health and behavior outcomes, and quality of life. Beyond these limitations, this review identified a list of future research directions in 6 categories. On the basis of the review findings, we provide practical recommendations to enhance FIVR reminiscence interventions, covering topics such as virtual reality content, device choice, intervention types, and the role and responsibility of facilitators.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>older adults</kwd>
        <kwd>fully immersive virtual reality</kwd>
        <kwd>reminiscence</kwd>
        <kwd>Alzheimer</kwd>
        <kwd>cognitive function</kwd>
        <kwd>mental health</kwd>
        <kwd>psychological well-being</kwd>
        <kwd>memory care</kwd>
        <kwd>dementia</kwd>
        <kwd>scoping review</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>In recent years, there has been a surge in groundbreaking technologies and their applications in transforming care, therapies, treatments, and health prevention for older adults. Fully immersive virtual reality (FIVR) is one among these rapidly evolving technologies applied in diverse interventions, including poststroke rehabilitation [<xref ref-type="bibr" rid="ref1">1</xref>], cognitive training for people with neurodegenerative diseases [<xref ref-type="bibr" rid="ref2">2</xref>], mobility and balance training [<xref ref-type="bibr" rid="ref3">3</xref>], and the reduction of depression [<xref ref-type="bibr" rid="ref4">4</xref>]. This paper examines the application of FIVR in reminiscence interventions through a scoping literature review, with a particular focus on people living with dementia or mild cognitive impairments.</p>
      </sec>
      <sec>
        <title>Reminiscence Interventions</title>
        <p>Reminiscence intervention is a type of nonpharmacological therapy [<xref ref-type="bibr" rid="ref5">5</xref>] that was developed in the 1960s and has gained popularity since the 1980s [<xref ref-type="bibr" rid="ref6">6</xref>]. Reminiscence is an act of recalling or retelling past experiences or facts [<xref ref-type="bibr" rid="ref7">7</xref>]. As an early advocate of this technique, Butler [<xref ref-type="bibr" rid="ref8">8</xref>] argued that reminiscence was an older person’s natural adaptive response to late-life developmental crises, with thoughts related to their approaching death. Used in life review therapy, reminiscence helps an older person reorganize past experiences, settle unresolved issues, bring new meaning to the present life, and better prepare for death [<xref ref-type="bibr" rid="ref8">8</xref>]. Molinari [<xref ref-type="bibr" rid="ref9">9</xref>] expanded on the notion proposed by Butler [<xref ref-type="bibr" rid="ref8">8</xref>] and purported that reminiscence activities could take many forms, including storytelling, autobiography, music, reunions, and scrapbooks. He suggested that reminiscence could be conducted in community or clinical settings, with a person or group of people, by laypersons, or by trained professionals; with structured or unstructured methods; or in a formal or casual format [<xref ref-type="bibr" rid="ref9">9</xref>]. However, many states in the United States, such as Texas, require counseling therapy to be delivered by licensed professionals [<xref ref-type="bibr" rid="ref10">10</xref>]; interventions done by family members, friends, and noncertified personnel may be referred to as informal exercises or activities.</p>
        <p>Pinquart and Forstmeier [<xref ref-type="bibr" rid="ref11">11</xref>] and Woods et al [<xref ref-type="bibr" rid="ref12">12</xref>] identified three main types of reminiscence interventions: (1) simple reminiscence, which involved the recall and sharing of positive memories and stories to increase positive feelings; (2) life review, which was conducted in a structured way with the whole-life story, seeking to integrate both negative and positive memories; and (3) life review therapy, which typically aimed at the reevaluation of negative memories, promoting a more positive view of life.</p>
        <p>According to Molinari [<xref ref-type="bibr" rid="ref9">9</xref>], reminiscence interventions help reshape a person’s views of life experiences and stories toward positive and coherent outcomes, focusing on strength, success, and lessons learned. Therefore, reminiscence interventions have been used in diverse settings for various purposes: in dementia and Alzheimer care to lessen behavioral and psychological symptoms and enhance cognitive function, social interaction, self-esteem, and quality of life [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]; in end-of-life care, such as hospices and palliative care, to enhance life satisfaction and reduce feelings of regret [<xref ref-type="bibr" rid="ref14">14</xref>]; in patients with cancer to lower anxiety and depression scales and increase hope, dignity, and quality of life [<xref ref-type="bibr" rid="ref15">15</xref>]; and in rehabilitation to motivate patients to actively participate in the rehabilitation process, fostering a sense of identity and continuity in their life story [<xref ref-type="bibr" rid="ref16">16</xref>]. Moreover, a literature review conducted by Shin et al [<xref ref-type="bibr" rid="ref17">17</xref>] revealed that a reminiscence intervention was effective in improving the quality of life and life satisfaction among community-dwelling older adults with no dementia symptoms.</p>
      </sec>
      <sec>
        <title>Cues for Reminiscence Interventions</title>
        <p>Similar to other psychotherapeutic interventions, a reminiscence session is primarily carried out through conversations, with a provider guiding the person to recall past events, discuss their meanings and impacts, resolve past conflicts, and pave the way for more positive views of the present life. Various media or artifacts that provide visual or audio cues have been applied to stimulate memory and prompt conversations, especially for those with memory problems.</p>
        <p>In a literature review, Lazar et al [<xref ref-type="bibr" rid="ref18">18</xref>] reported that common media for reminiscence interventions included text, videos, photographs, images, music, audio, and personal objects and artifacts such as toys, which were closely related to the person’s past experience. The authors also revealed that the technologies to present these media ranged from slide projectors and tape recorders from the 1990s to touchscreen tablets in the early 2010s [<xref ref-type="bibr" rid="ref19">19</xref>-<xref ref-type="bibr" rid="ref21">21</xref>]. Moreover, digital technologies have since created more innovative alternatives to aid reminiscence [<xref ref-type="bibr" rid="ref22">22</xref>-<xref ref-type="bibr" rid="ref25">25</xref>]. For example, personalized digital memory books and multisensory mobile multimedia environments delivered more content or multiple stimuli in convenient ways [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
        <p><xref rid="figure1" ref-type="fig">Figure 1</xref> [<xref ref-type="bibr" rid="ref19">19</xref>-<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>] shows the timeline of different technologies used in reminiscence interventions since 1992. It is worth noting that therapists may have used technologies to aid reminiscence activities in earlier years, but this was not documented in peer-reviewed publications.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Timeline of the technologies applied to reminiscence interventions documented in peer-reviewed publications. VR: virtual reality.</p>
          </caption>
          <graphic xlink:href="games_v11i1e45539_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Virtual Reality as an Aid to Reminiscence</title>
        <p>Virtual reality (VR) uses computer simulation to provide realistic visual and tactile experiences in a 3D virtual world. VR appears in many forms: (1) nonimmersive, in which a computer or television screen is used to display the content; (2) semi-immersive, in which multiple screens or a Cave Automatic Virtual Environment display present the virtual environment surrounding the participant [<xref ref-type="bibr" rid="ref28">28</xref>]; and (3) fully immersive, in which the participant wears the VR head-mounted display or haptic devices to be fully immersed in the virtual world. According to Logan [<xref ref-type="bibr" rid="ref29">29</xref>], VR possesses three main characteristics: (1) interactivity, whereby the user can interact with the virtual world through commands; (2) immersion, whereby the user should have similar authentic feelings, through different sensors, such as those in real environments; and (3) imagination, whereby the user should be able to imagine beyond the virtual world, finding new perspectives or new ways to solve problems.</p>
        <p>VR has been applied in a variety of interventions for older adults. D’Cunha et al [<xref ref-type="bibr" rid="ref30">30</xref>] conducted a literature review on the application of VR and augmented reality in nonpharmacological interventions, examining their effectiveness in promoting psychological health and users’ experience. Three types of interventions were tested in the reviewed studies: (1) cognitive or memory training; (2) reminiscence; and (3) therapeutic activities, including physical exercises. The results showed that VR and augmented reality were preferred and well accepted by people living with dementia or mild cognitive impairment and that these technologies helped improve mood, apathy, and cognitive functions. However, some side effects raised concerns about negative feelings after the reminiscence sessions that triggered participants’ unpleasant memories. Although immersive VR was used in some studies selected by the authors, most of them were semi-immersive but did not use a head-mounted display that would provide a fully immersive experience.</p>
        <p>Although the first head-mounted VR display with 3D graphics and head tracking was invented in the 1960s [<xref ref-type="bibr" rid="ref31">31</xref>], it was not until the last decade, marked by the introduction of the first consumer-grade VR headset (Oculus Rift) in 2011, that FIVR became more affordable, more technically accessible, and easier to use [<xref ref-type="bibr" rid="ref32">32</xref>]. FIVR has been popular in a variety of fields such as gaming, education, professional training, medical practice, therapies, and research [<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref37">37</xref>]. With its capability to promote interactivity, immersion, and imagination, FIVR may be an excellent aid for reminiscence interventions by stimulating or reactivating the past memories of older adults, especially those living with mild cognitive impairment or dementia.</p>
      </sec>
      <sec>
        <title>Reminiscence Interventions for People Living With Dementia or Mild Cognitive Impairments</title>
        <p>Population aging has brought about a rapid increase in the number of older adults with cognitive and behavioral problems. Rajan et al [<xref ref-type="bibr" rid="ref38">38</xref>] estimated that 12.23 million Americans aged ≥65 years experienced mild cognitive impairments in 2020 and that this number would rise to 21.55 million in 2060. The Alzheimer’s Association reported that 10% to 15% of people with mild cognitive impairment transitioned to dementia each year [<xref ref-type="bibr" rid="ref39">39</xref>]. Furthermore, approximately 1 in 9 older adults (10.7%) in the United States had Alzheimer disease, accounting for 60% to 80% of people living with dementia. Cognitive impairment affecting memory, language, orientation, attention, and judgment leads to behavioral and psychological disturbances, dysfunction in activities of daily living, and instrumental activities of daily living [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. Such functional disabilities and behavioral problems have added to caregivers’ and family members’ burdens and strained health care resources [<xref ref-type="bibr" rid="ref43">43</xref>].</p>
        <p>According to the Alzheimer’s Association, pharmacological and nonpharmacological options may be available to treat cognitive impairments, depending on their causes [<xref ref-type="bibr" rid="ref39">39</xref>]. However, pharmacological treatment options are limited, with only 6 drugs—specifically for Alzheimer disease—currently approved by the US Food and Drug Administration [<xref ref-type="bibr" rid="ref39">39</xref>]. In addition, there is evidence that pharmacological treatments for behavioral and psychological symptoms of people living with dementia often come with adverse side effects, including an increased risk of falls and fractures, stroke, and even mortality and limited efficacy in symptom management [<xref ref-type="bibr" rid="ref44">44</xref>]. Nonpharmacological therapies are safer options with manageable side effects for people with cognitive impairments than pharmacological treatments. These therapies can help reduce anxiety, depression, apathy, irritation, and other negative emotions and possibly decrease the need for pain and psychoactive medications by not inducing biological changes [<xref ref-type="bibr" rid="ref45">45</xref>]. After reviewing the literature, Cammisuli et al [<xref ref-type="bibr" rid="ref5">5</xref>] categorized nonpharmacological interventions into four main categories: (1) holistic techniques, including reality orientation that helps people living with dementia be aware of who and where they are and what time it is; cognitive stimulation therapy that uses a series of objects, themes, or activities, such as physical games, sounds, food, current affairs, scenes, word association, using money, and number games to stimulate cognitive functioning; and reminiscence; (2) brief psychotherapies, a type of psychodynamic therapy that emphasizes the identity of people living with dementia through a conversation about past experience, with the aim of reducing emotional distress and other behavioral problems; (3) cognitive methods, such as the space retrieval technique, which trains people living with dementia to regain the ability to associate names with human faces or with objects; and (4) alternative strategies, such as music therapy and bright light therapy [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
        <p>As previously noted, Cammisuli et al [<xref ref-type="bibr" rid="ref5">5</xref>] categorized reminiscence interventions as a holistic technique of nonpharmacological therapy. Evidence has shown that appropriate reminiscence interventions for older adults with cognitive impairment can effectively evoke memories, alleviate anxiety and depression, reduce stress, manage cognitive decline, increase self-esteem, and improve quality of life [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. Importantly, these interventions may potentially lower caregivers’ burden and stress due to the improvement in their care recipients’ psychological, mental, and behavioral health [<xref ref-type="bibr" rid="ref48">48</xref>], which is significant as the world is experiencing a serious shortage in the nursing workforce.</p>
      </sec>
      <sec>
        <title>Research Aims</title>
        <p>We found little collective knowledge on how FIVR works in reminiscence interventions. Therefore, this scoping review aimed to assess and synthesize existing evidence regarding the influence and effectiveness of FIVR as an aid in reminiscence interventions. We expected the findings to elucidate potential directions for future research, offer recommendations for practice, and address the critical needs of caring for frail older adults, particularly those living with dementia and mild cognitive impairments.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Overview</title>
        <p>We adopted PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews) to map the evidence for FIVR-based reminiscence interventions. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is a minimum set of evidence-based items for reporting in systematic reviews and meta-analyses [<xref ref-type="bibr" rid="ref49">49</xref>]. The PRISMA-ScR—with 20 essential reporting items and 2 optional items—was created to synthesize evidence and assess the scope of the literature on a topic [<xref ref-type="bibr" rid="ref50">50</xref>]. The detailed descriptions of the 22 items are reported in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. Compared with systematic reviews, scoping reviews address a broader research question [<xref ref-type="bibr" rid="ref51">51</xref>]. They allow researchers to identify the scope of the literature in a certain area, provide a clear indication of the available literature and an overview of its focus, and examine emerging evidence that informs field practice [<xref ref-type="bibr" rid="ref51">51</xref>]. We adopted the scoping review approach because it perfectly aligns with our study’s aims.</p>
      </sec>
      <sec>
        <title>Search, Screening, and Selection</title>
        <p>We applied the following inclusion and exclusion criteria for article selection: (1) the use of FIVR as an aid for reminiscence interventions; (2) the inclusion of adults aged ≥65 years; (3) reporting on empirical studies; (4) reporting on outcomes related to health and well-being and the feasibility or usability of FIVR; (5) publication in English; and (6) publication in peer-reviewed journals or peer-reviewed conference proceedings between January 1, 2000, and August 1, 2022. Electronic databases—PubMed, PsycINFO, Embase, CINAHL, Web of Science, ACM, and IEEE Xplore—were used for the literature search. The search terms included all possible synonyms and combinations of “Reminiscence Interventions and/or Therapies” (reminiscence, life story, reminisc* therapy*, and memory simulation) and “Virtual Reality” (VR, imagined 3D environment, and simulat* environment).</p>
        <p>First, a researcher used a consistent set of keywords to search each database between March and August 2022. The search results were imported and organized using Endnote X9 (Clarivate), a computer reference management program. Second, 2 researchers scanned the titles and subsequently the abstracts of the retrieved articles. They then independently reviewed the full texts, collating all eligible articles. References from these articles were also scrutinized to capture any potentially overlooked information in the initial database search. Subsequently, the researchers deliberated each article in detail, deciding on its inclusion based on predetermined criteria and the study objectives. In case of any disagreements between the 2 researchers, a third researcher was ready to intervene with a final decision. However, this contingency was not triggered.</p>
      </sec>
      <sec>
        <title>Data Extraction and Analysis</title>
        <p>We continued to use Endnote X9 to manage the selected articles and Microsoft Excel spreadsheets for data extraction. The categories of the data included title, author, year of publication, publication type such as journal or conference paper, research design, research questions, intervention information including reminiscence types, VR contents, VR types, and devices, and participant information, measurements, results, study limitations, and future research questions. One researcher charted the data into a spreadsheet, whereas another oversaw the process, critically assessed the extraction, and made necessary adjustments based on joint discussions when a disagreement arose. The charted data were further summarized and analyzed by both researchers.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Search Results</title>
        <p>The screening and selection process for eligible articles is shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>. Additional details can be found in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. The first search resulted in 742 articles from the databases and 64 others from further sources such as references of selected articles. After removing the duplicates, 700 articles were retained. After the authors screened each article’s title and abstract, 174 articles remained in the pool. We quickly scanned the full text and retained 56 articles for additional evaluation. Through the detailed full-text reviews, 45 studies were excluded according to the inclusion criteria, with specific reasons documented in <xref rid="figure2" ref-type="fig">Figure 2</xref>. Finally, 11 studies were identified for this scoping review [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref60">60</xref>].</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram of the literature search and screening process. VR: virtual reality.</p>
          </caption>
          <graphic xlink:href="games_v11i1e45539_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Characteristics of the Selected Studies</title>
        <p><xref ref-type="table" rid="table1">Table 1</xref> summarizes the general information of the selected studies, including basic article information such as authors, year of publication, and research design.</p>
        <p>Nine articles were published in peer-reviewed journals and 2 in peer-reviewed conference proceedings. There were 4 studies that were conducted in Australia [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>], 4 in Asia (China, Taiwan, and Japan) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], 2 in Europe (Germany and Portugal) [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], and 1 in the United States [<xref ref-type="bibr" rid="ref52">52</xref>]. The years of publication were between 2018 and 2022.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>General information summaries of selected studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="230"/>
            <col width="370"/>
            <col width="400"/>
            <thead>
              <tr valign="top">
                <td>Study, year</td>
                <td>Publication type (study location)</td>
                <td>Research design</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2021</td>
                <td>Journal paper (United States)</td>
                <td>Mixed methods</td>
              </tr>
              <tr valign="top">
                <td>Baker et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                <td>Conference paper (Australia)</td>
                <td>Qualitative research</td>
              </tr>
              <tr valign="top">
                <td>Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2020</td>
                <td>Journal paper (Portugal)</td>
                <td>Mixed methods</td>
              </tr>
              <tr valign="top">
                <td>Huang and Yang [<xref ref-type="bibr" rid="ref54">54</xref>], 2022</td>
                <td>Journal paper (Taiwan)</td>
                <td>Quantitative research</td>
              </tr>
              <tr valign="top">
                <td>Klein et al [<xref ref-type="bibr" rid="ref25">25</xref>], 2018</td>
                <td>Journal paper (Germany)</td>
                <td>Qualitative research</td>
              </tr>
              <tr valign="top">
                <td>Niki et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2020</td>
                <td>Journal paper (Japan)</td>
                <td>Quantitative research with randomized crossover research design</td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>], 2020</td>
                <td>Journal paper (Australia)</td>
                <td>Mixed methods</td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2021</td>
                <td>Journal paper (Australia)</td>
                <td>Quantitative research with multisite nonrandomized controlled trial</td>
              </tr>
              <tr valign="top">
                <td>Webber et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2021</td>
                <td>Journal paper (Australia)</td>
                <td>Qualitative research</td>
              </tr>
              <tr valign="top">
                <td>Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                <td>Conference paper (China)</td>
                <td>Randomized controlled trial</td>
              </tr>
              <tr valign="top">
                <td>Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                <td>Journal paper (Japan)</td>
                <td>Case study</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Participant Characteristics</title>
        <p><xref ref-type="table" rid="table2">Table 2</xref> lists the participant characteristics of the included studies. All the studies involved older participants, with an average age between 80 and 90 years in 6 studies and 70 and 80 years in 3 studies. Two articles did not specify the participants’ ages. All but one study included participants with cognitive impairments. Three studies specifically stated that they recruited people living with dementia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. Three studies reported other health problems in their participants, including depression, anxiety, heart diseases, mental health issues, mobility challenges, hearing difficulty, Parkinson disease, and stroke [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>].</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>General participant information.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="140"/>
            <col width="330"/>
            <col width="250"/>
            <col width="280"/>
            <thead>
              <tr valign="top">
                <td>Study, year</td>
                <td>Sample size, gender, and age</td>
                <td>Cognitive or dementia conditions</td>
                <td>Other health conditions</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>21 residents (female: n=18, male: n=3; mean age 83.1, SD 3.72 y) with their family members (female: n=9, male: n=12; mean age 59.86, SD 14.12 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Mild cognitive impairment (n=9)</p>
                    </list-item>
                    <list-item>
                      <p>Mild dementia (n=4)</p>
                    </list-item>
                    <list-item>
                      <p>Moderate dementia (n=8)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Baker et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>16 older adults (female: n=5, male: n=11)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Hearing difficulty (n=4)</p>
                    </list-item>
                    <list-item>
                      <p>Need mobility aid (n=2)</p>
                    </list-item>
                    <list-item>
                      <p>Mental health problem (n=1)</p>
                    </list-item>
                    <list-item>
                      <p>Parkinson disease with communication or movement problem (n=1)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>9 individuals (female: n=6, male: n=3; mean age 85.6, SD 7.4 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Dementia (n=9)</p>
                    </list-item>
                    <list-item>
                      <p>Moderate cognitive decline (n=3)</p>
                    </list-item>
                    <list-item>
                      <p>Moderately severe cognitive decline (n=3)</p>
                    </list-item>
                    <list-item>
                      <p>Severe cognitive decline (n=3)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Huang and Yang [<xref ref-type="bibr" rid="ref54">54</xref>], 2022</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>20 participants (female: n=11, male: n=9; mean age 79.0, SD 7.8 y)</p>
                    </list-item>
                    <list-item>
                      <p>Among the 20 participants, 7 were assessed 3-6 mo after the intervention</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Very mild dementia (n=2)</p>
                    </list-item>
                    <list-item>
                      <p>Mild dementia (n=15)</p>
                    </list-item>
                    <list-item>
                      <p>Moderate dementia (n=3)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Klein et al [<xref ref-type="bibr" rid="ref25">25</xref>], 2018</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>6 participants (female: n=3, male: n=3; mean age 74.67, SD 1.31 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Dementia (n=4)</p>
                    </list-item>
                    <list-item>
                      <p>Cognitive impairment without an unequivocal diagnosis of dementia (n=2)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Niki et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>10 individuals (female: n=6, male: n=4; mean age 87.1, SD 4.2 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Normal cognition (n=9)</p>
                    </list-item>
                    <list-item>
                      <p>Suspected mild cognitive impairment (n=1)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>17 participants (female: n=10, male: n=7; mean age 87.3, SD 6.3 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>No or minimal cognitive impairment (n=10)</p>
                    </list-item>
                    <list-item>
                      <p>Mild cognitive impairments (n=3)</p>
                    </list-item>
                    <list-item>
                      <p>Moderate cognitive impairments (n=4)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Depressive symptoms (n=6)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Experiment group: 15 participants (female: n=10, male: n=5; mean age 81.7, SD 6.6 y)</p>
                    </list-item>
                    <list-item>
                      <p>Active control: 14 participants (female: n=9, male: n=5; mean age 85.9, SD 8.1 y)</p>
                    </list-item>
                    <list-item>
                      <p>Passive control: 14 participants (female: n=9, male: n=5; mean age 87, SD 8.7 y)</p>
                    </list-item>
                    <list-item>
                      <p>Total: 43 participants (female: n=28, male: n=15; mean age 84.8, SD 8 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Memory-related dementia or Parkinson disease (n=5)</p>
                    </list-item>
                    <list-item>
                      <p>Memory-related dementia or Parkinson disease (n=3)</p>
                    </list-item>
                    <list-item>
                      <p>Memory-related, dementia or Parkinson disease (n=3)</p>
                    </list-item>
                    <list-item>
                      <p>Memory-related dementia or Parkinson disease (n=11)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Depression (n=5)</p>
                    </list-item>
                    <list-item>
                      <p>Anxiety (n=5)</p>
                    </list-item>
                    <list-item>
                      <p>Heart disease (n=8)</p>
                    </list-item>
                    <list-item>
                      <p>Stroke (n=2)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Webber et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>6 participants + 1 participant in pilot study</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>With signs of cognitive impairment (n=4)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Virtual reality–based group: 10 participants (female: n=5, male: n=5; mean age 76.7, SD 5.5 y)</p>
                    </list-item>
                    <list-item>
                      <p>Photo-based group: 10 participants (female: n=8, male: n=3; mean age 79.4, SD 2.0 y)</p>
                    </list-item>
                    <list-item>
                      <p>Blank group (verbally guided): 10 participants (mean age 78.5, SD 3.4 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Mild to moderate dementia</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>2 participants (female: n=1, male: n=1; age 80 and 92 y)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Mild cognitive impairment (n=2)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Not specified</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Research Designs</title>
        <p>There was 1 randomized crossover trial [<xref ref-type="bibr" rid="ref55">55</xref>] and 1 randomized controlled trial [<xref ref-type="bibr" rid="ref59">59</xref>]. Two quasi-experiments with pre-post comparisons were included [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], one of which had a control group. Another quasi-experiment was conducted with pre-post comparisons, wherein the intervention was offered twice a week over a 3-month period. Assessments were performed immediately and 3 to 6 months after the intervention [<xref ref-type="bibr" rid="ref53">53</xref>]. The remaining studies included 3 qualitative studies [<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>], 2 mixed methods studies [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>], and 1 case study [<xref ref-type="bibr" rid="ref60">60</xref>]. The sample sizes ranged from 2 to 43.</p>
      </sec>
      <sec>
        <title>FIVR Instruments and Stimuli</title>
        <p><xref ref-type="table" rid="table3">Tables 3</xref> and <xref ref-type="table" rid="table4">4</xref> summarize the VR-related information of the selected studies, including VR types and visual contents, outcome measures, measurement methods, and results.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Virtual reality (VR) types and visual contents used in the selected studies.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="160"/>
            <col width="370"/>
            <col width="470"/>
            <thead>
              <tr valign="top">
                <td>Study, year</td>
                <td>VR type</td>
                <td>Visual content</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                    <list-item>
                      <p>Video based</p>
                    </list-item>
                    <list-item>
                      <p>Computer graphic based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Virtual adventures</p>
                    </list-item>
                    <list-item>
                      <p>Virtual life story</p>
                    </list-item>
                    <list-item>
                      <p>Virtual photos and videos</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Baker et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Computer graphic based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>School hall and classroom</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Video based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Specific streets, squares, gardens, churches, and historical landmarks that were meaningful to participants</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Huang and Yang [<xref ref-type="bibr" rid="ref54">54</xref>], 2022</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Computer graphic based (with customized narration and music that was significant to the person)</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Historical type of residence commonly found throughout Taiwan from 1960-1980</p>
                    </list-item>
                    <list-item>
                      <p>Interactive features: the participant could use controller to hold rice to fee chickens</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Klein et al [<xref ref-type="bibr" rid="ref25">25</xref>], 2018</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                    <list-item>
                      <p>Video based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Time travel (Berlin, 1949-1970; Paris, 20th century), movie stars (1950-1960), Germany television shows (later 20th century), or handicraft images</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Niki et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                    <list-item>
                      <p>Computer graphic based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>A theme park with 6 familiar situations to those aged ≥75 y</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Personal tailored content</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Personal tailored content (not specified)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Webber et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Personal nominated content</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Computer graphic based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>A Chinese rural cottage in the 1970s with an area of 30 m2</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Photo based</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Personal memorable places (not specified)</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Measures, measurement instruments, and results.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="129"/>
            <col width="289"/>
            <col width="246"/>
            <col width="336"/>
            <thead>
              <tr valign="top">
                <td>Study, year</td>
                <td>Measure</td>
                <td>Measurement instruments</td>
                <td>Results</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>User satisfaction and perceptions</p>
                    </list-item>
                    <list-item>
                      <p>Conversational and behavioral engagement</p>
                    </list-item>
                    <list-item>
                      <p>Kinesics engagement</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Coding analysis of video recording</p>
                    </list-item>
                    <list-item>
                      <p>Coding analysis of video recording</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>VR<sup>a</sup> deemed to be safe, extremely enjoyable, and easy to use by residents and family members</p>
                    </list-item>
                    <list-item>
                      <p>Residents being more conversationally and behaviorally engaged with their family members in VR sessions than in the baseline telephone calls</p>
                    </list-item>
                    <list-item>
                      <p>Residents with dementia reporting greater immersion in the VR than residents with MCI<sup>b</sup></p>
                    </list-item>
                    <list-item>
                      <p>Residents with MCI being more kinetically engaged while using the VR than residents with dementia.</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Baker et al [<xref ref-type="bibr" rid="ref53">53</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Older adults’ ability to participate</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Questionnaire, interviews, screen-captured video, observation notes, photographs, and short video recordings</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>The virtual environment playing an effective role in surfacing memories and scaffolding reminiscence</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Engagement and behavior</p>
                    </list-item>
                    <list-item>
                      <p>Manifestation of psychological and behavioral symptoms</p>
                    </list-item>
                    <list-item>
                      <p>Specific symptoms associated with simulation experiences</p>
                    </list-item>
                    <list-item>
                      <p>Psychological and behavioral symptomatology and the quality of life</p>
                    </list-item>
                    <list-item>
                      <p>Caregivers’ opinion</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Coding analysis of observation</p>
                    </list-item>
                    <list-item>
                      <p>Coding analysis of observation</p>
                    </list-item>
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Structured interview with a knowledgeable informant</p>
                    </list-item>
                    <list-item>
                      <p>Semistructured interview</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Participants being very interested in exploring the immersive virtual environment and addressing positive or happy memories with frequently spontaneous communications and without simulator sickness in most cases</p>
                    </list-item>
                    <list-item>
                      <p>No significant differences found in psychological and behavioral symptomatology and the quality of life</p>
                    </list-item>
                    <list-item>
                      <p>Potentially beneficial experience for most participants reported by caregivers</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Huang and Yang [<xref ref-type="bibr" rid="ref54">54</xref>], 2022</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Overall cognitive function</p>
                    </list-item>
                    <list-item>
                      <p>Cognitive impairment</p>
                    </list-item>
                    <list-item>
                      <p>Dementia status</p>
                    </list-item>
                    <list-item>
                      <p>Depression</p>
                    </list-item>
                    <list-item>
                      <p>Caregiver burden</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>CASI<sup>c</sup></p>
                    </list-item>
                    <list-item>
                      <p>MMSE<sup>d</sup></p>
                    </list-item>
                    <list-item>
                      <p>CDR<sup>e</sup> and its CDR-SB<sup>f</sup></p>
                    </list-item>
                    <list-item>
                      <p>CESD<sup>g</sup></p>
                    </list-item>
                    <list-item>
                      <p>ZBI<sup>h</sup></p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>No significant differences in cognition (MMSE and CASI), global status of dementia (CDR-SB), and caregiver burden (ZBI) scores before and immediately after the intervention</p>
                    </list-item>
                    <list-item>
                      <p>No significant differences in MMSE, global status of dementia (CDR-SB), and caregiver burden (ZBI) scores immediately after the intervention and 3-6 mo after the intervention</p>
                    </list-item>
                    <list-item>
                      <p>Significantly decreased cognitive abilities (CASI) 3-6 mo after the intervention compared with those immediately after the intervention</p>
                    </list-item>
                    <list-item>
                      <p>Significantly improved depression (CESD) symptom immediately after the intervention</p>
                    </list-item>
                    <list-item>
                      <p>Significantly improved depression (CESD) symptom 3-6 mo after the intervention, compared with those immediately after the intervention</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Klein et al [<xref ref-type="bibr" rid="ref25">25</xref>], 2018</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>“Destructive” and “supportive” behaviors</p>
                    </list-item>
                    <list-item>
                      <p>Usability</p>
                    </list-item>
                    <list-item>
                      <p>Caregivers’ recommendations and assessment of feasibility</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Rating with a qualitative behavioral protocol</p>
                    </list-item>
                    <list-item>
                      <p>Rating with ISO 9241-110 criteria</p>
                    </list-item>
                    <list-item>
                      <p>Semistructured interview</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>The prototype fostering conversations between participants and caregivers, positive interactions, and more “supportive” behaviors (eg, recognition, celebration, relaxation, validation, and facilitation) than “destructive” behaviors (eg, outpacing, ignoring, and imposition).</p>
                    </list-item>
                    <list-item>
                      <p>The prototype deemed to be suitable for daily care but being needed to be more fluently and with a bigger angle by caregivers</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Niki et al [<xref ref-type="bibr" rid="ref55">55</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Anxiety</p>
                    </list-item>
                    <list-item>
                      <p>Satisfaction and side effects</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>VR reminiscence reducing anxiety without causing serious side effects.</p>
                    </list-item>
                    <list-item>
                      <p>VR with live-action images being preferred by participants than computer graphics images</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Apathy; side effect; realistic experience</p>
                    </list-item>
                    <list-item>
                      <p>Verbal fluency</p>
                    </list-item>
                    <list-item>
                      <p>Expectations or enjoyment</p>
                    </list-item>
                    <list-item>
                      <p>Debriefing</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Task</p>
                    </list-item>
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Enjoyable and acceptable experience with some negative symptoms or side effects reported by all study particiapnts</p>
                    </list-item>
                    <list-item>
                      <p>Improved semantic scores but not phonemic fluency scores found in participants</p>
                    </list-item>
                    <list-item>
                      <p>Greatest cognitive improvements after a VR reminiscence experience found in participants with higher levels of apathy</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Apathy</p>
                    </list-item>
                  </list>
                  <list list-type="bullet">
                    <list-item>
                      <p>Cognition</p>
                    </list-item>
                    <list-item>
                      <p>Depression; quality of life; loneliness; side effect</p>
                    </list-item>
                    <list-item>
                      <p>Staff’s opinions</p>
                    </list-item>
                    <list-item>
                      <p>Attendance and responses</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Examination</p>
                    </list-item>
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Staff questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Coding analysis of recordings</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Most participants in the VR group preferring to watch content in VR than on a flat screen.</p>
                    </list-item>
                    <list-item>
                      <p>Participants enjoying the process of reminiscence</p>
                    </list-item>
                    <list-item>
                      <p>Participants reporting their willingness to do reminiscence again.</p>
                    </list-item>
                    <list-item>
                      <p>No significant results observed for cognition, depression, quality of life, and loneliness after therapy</p>
                    </list-item>
                    <list-item>
                      <p>No reported significant side effects or discomfort</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Webber et al [<xref ref-type="bibr" rid="ref58">58</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Perceived value; varied forms of reminiscence; challenges</p>
                    </list-item>
                    <list-item>
                      <p>Motivation and expectation</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Observation, semistructured interviews, and questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Interviews with family members</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Various past memories being elicited for all participants with mixed feelings expressed by several participants.</p>
                    </list-item>
                    <list-item>
                      <p>Virtual visits prompting various forms of reminiscence without noticeably differences compared with tablet computers.</p>
                    </list-item>
                    <list-item>
                      <p>Diverse expectations about the potential value of virtual visits revealed by families</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>], 2020</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Acceptability (motivation, presence, and VR sickness)</p>
                    </list-item>
                    <list-item>
                      <p>Autobiographical memory</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Rating with video recording</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>The VR group and the photo group with higher scores in recalling autobiographical memory than the blank group, with no significant difference between the VR group and the photo group</p>
                    </list-item>
                    <list-item>
                      <p>Higher levels of interest, motivation and perceived security, and lower levels of anxiety and fatigue in participants in both the VR group and the photo group than those in the blank group</p>
                    </list-item>
                    <list-item>
                      <p>Significantly higher level of pleasure reported in the VR group than those in the photo group.</p>
                    </list-item>
                    <list-item>
                      <p>High levels of presence with negligible sickness symptoms in the VR group</p>
                    </list-item>
                  </list>
                </td>
              </tr>
              <tr valign="top">
                <td>Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>], 2021</td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Anxiety; side effect and satisfaction; motivation</p>
                    </list-item>
                    <list-item>
                      <p>The burden of care</p>
                    </list-item>
                    <list-item>
                      <p>Attitude toward participation in the study</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Self-report questionnaire</p>
                    </list-item>
                    <list-item>
                      <p>Questionnaire by family members</p>
                    </list-item>
                    <list-item>
                      <p>Coding analysis of observations and videos</p>
                    </list-item>
                  </list>
                </td>
                <td>
                  <list list-type="bullet">
                    <list-item>
                      <p>Reduced anxiety and the burden of care without serious side effects by IVR<sup>i</sup> reminiscence</p>
                    </list-item>
                    <list-item>
                      <p>Similar effectiveness found between remote IVR reminiscence and the face-to-face session</p>
                    </list-item>
                  </list>
                </td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>VR: virtual reality.</p>
            </fn>
            <fn id="table4fn2">
              <p><sup>b</sup>MCI: mild cognitive impairment.</p>
            </fn>
            <fn id="table4fn3">
              <p><sup>c</sup>CASI: Cognitive Abilities Screening Instrument.</p>
            </fn>
            <fn id="table4fn4">
              <p><sup>d</sup>MMSE: Mini-Mental State Examination.</p>
            </fn>
            <fn id="table4fn5">
              <p><sup>e</sup>CDR: Clinical Dementia Rating.</p>
            </fn>
            <fn id="table4fn6">
              <p><sup>f</sup>CDR-SB: Clinical Dementia Rating–Sum of Boxes.</p>
            </fn>
            <fn id="table4fn7">
              <p><sup>g</sup>CESD: Center for Epidemiological Studies Depression.</p>
            </fn>
            <fn id="table4fn8">
              <p><sup>h</sup>ZBI: Zarit Caregiver Burden Interview.</p>
            </fn>
            <fn id="table4fn9">
              <p><sup>i</sup>IVR: immersive virtual reality.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <p>The VR goggles developed by Oculus were used in most studies (n=8): Oculus Go in 5 studies [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], Oculus Rift in 2 studies [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref54">54</xref>], and Oculus Quest in 1 study [<xref ref-type="bibr" rid="ref57">57</xref>]. Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>] used Samsung Gear VR as a head-mounted display in addition to the Oculus Rift. Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>] adopted the HTC VIVE Focus headset. Huang and Yang [<xref ref-type="bibr" rid="ref53">53</xref>] used the HTC VIVE Pro version. Klein et al [<xref ref-type="bibr" rid="ref30">30</xref>] developed a VR goggle—the “Binoculars” prototype—for their own project.</p>
        <p>We divided FIVR stimuli into three categories: (1) photo based, which used 360° photos of real environments; (2) video based, which used 360° videos of real environments; and (3) computer graphic based, which used 360° images or animations of virtual environments generated by computer 3D modeling programs. Seven studies used photo-based VR stimuli [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Five studies used computer graphics–based VR, one of which incorporated recorded customized narrative and simple interactive functions via VR handles [<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. Two studies applied video-based VR [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref30">30</xref>], whereas 3 adopted ≥2 types of VR stimuli [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>].</p>
      </sec>
      <sec>
        <title>Types of Reminiscence Interventions</title>
        <p>Only the study conducted by Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>] specified the type of reminiscence intervention used: a semistructured simple reminiscence approach emphasizing positive memories. The 2 other possible approaches, “life review” and “life story review,” were not found in the rest of the articles.</p>
        <p>Reminiscence interventions in the selected studies can be categorized based on the way they were conducted (group or individual) and the people involved (certified therapists, caregivers, or researchers). Eight studies were conducted using an individual format. Only the study by Baker et al [<xref ref-type="bibr" rid="ref54">54</xref>] investigated how VR applications facilitated group reminiscence, in which participants communicated with each other and with a facilitator who was determined before the conversation started. During the interventions, 5 studies used researchers as facilitators [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>-<xref ref-type="bibr" rid="ref58">58</xref>]. One study used a professional team comprising pharmacists, an occupational therapist, a clinical psychologist, a certified psychologist, and a pharmacy student [<xref ref-type="bibr" rid="ref60">60</xref>]. Interventions in 2 studies were conducted by researchers accompanied by caregivers or nursing staff [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. All but 2 were conducted only through face-to-face meetings [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Participants in the study by Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>] experienced the FIVR scenarios simultaneously with their family members who lived at a distance, interacting with each other remotely.</p>
      </sec>
      <sec>
        <title>Health-Related and Behavior-Related Outcomes</title>
        <p>All studies reported health- and behavior-related outcomes after reminiscence interventions. For the participants, we identified seven types of health- and behavior-related outcomes reported in the studies: (1) anxiety, (2) apathy, (3) cognitive functions or dementia status, (4) engagement, (5) depression, (6) loneliness, and (7) fatigue.</p>
        <sec>
          <title>Anxiety</title>
          <p>Three studies examined the effect of FIVR reminiscence on anxiety [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Instruments for measuring anxiety included the State-Trait Anxiety Inventory Self-Report Questionnaire [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], the Cornell Scale for Depression in Dementia, and the Neuropsychiatric Inventory [<xref ref-type="bibr" rid="ref40">40</xref>]. Niki et al [<xref ref-type="bibr" rid="ref55">55</xref>] found that FIVR reminiscence interventions reduced anxiety in older adults after the first session, maintaining effectiveness after the second [<xref ref-type="bibr" rid="ref55">55</xref>]. They discovered that 360° photos are more effective than computer-generated graphics. Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>] compared face-to-face and remote FIVR reminiscence sessions in 2 participants with mild cognitive impairments. Both participants experienced significantly decreased anxiety after the face-to-face sessions. However, after shifting to the remote session, 1 participant displayed a slight increase in anxiety, possibly due to the difficulty in remote communication, whereas the other participant’s anxiety level continued to decrease. In the study by Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>], some participants exhibited mild or intermittent anxiety and agitated behaviors during VR reminiscence sessions, which might have been caused by the disruption of participants’ daily routines and unfamiliarity with the experiment environment [<xref ref-type="bibr" rid="ref40">40</xref>].</p>
        </sec>
        <sec>
          <title>Apathy</title>
          <p>Apathy is defined as a “lack of feeling or emotion” or a “lack of interest or concern” [<xref ref-type="bibr" rid="ref61">61</xref>]. Four studies assessed participants’ changes in apathy after FIVR reminiscence interventions [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>] evaluated the effect of FIVR reminiscence therapy on apathy through verbal fluency and the Apathy Evaluation Scale. Verbal fluency, as noted by the authors, demonstrates the capability for executive control and initiation. The decline in these executive functions was associated with decreased apathy. They found that participants had improved semantic scores—the ability to name as many words as possible, starting with specific letters but not phonemic fluency scores and the ability to list more words in the category of either animals or fruit or vegetables—after the reminiscence session [<xref ref-type="bibr" rid="ref56">56</xref>]. In another study conducted by the same team, there was an improvement in participants’ apathy scale scores after reminiscence interventions [<xref ref-type="bibr" rid="ref57">57</xref>]. Using the Cornell Scale for Depression in Dementia and the Neuropsychiatric Inventory, Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>] found no significant improvement of apathy. Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>] assessed participants’ motivations and found that the effects of FIVR reminiscence on participants’ apathy levels were mixed.</p>
        </sec>
        <sec>
          <title>Cognitive Functions and Dementia Status</title>
          <p>Three studies assessed the effects of the FIVR reminiscence intervention on participants’ cognitive functions or dementia status, using measurement tools including the Cognitive Abilities Screening Instrument, the Mini-Mental State Examination, the Clinical Dementia Rating, the Addenbrooke Cognitive Examination III, and the Psychogeriatric Assessment Scales [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. Two studies reported nonsignificant findings [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. Huang and Yang [<xref ref-type="bibr" rid="ref53">53</xref>] noted no significant cognitive ability differences before and immediately after the intervention, but the scores significantly declined 3 to 6 months later, implicating that the intervention might help sustain participants’ cognitive functions [<xref ref-type="bibr" rid="ref53">53</xref>]. In addition, Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>] observed that participants with higher apathy levels showed greater cognitive improvement after the intervention.</p>
        </sec>
        <sec>
          <title>Engagement</title>
          <p>Engagement was evaluated in 3 studies through observations [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. Afifi et al [<xref ref-type="bibr" rid="ref52">52</xref>] stated that participants were more engaged in conversations and behaviors with their family after FIVR reminiscence sessions. Those with mild cognitive impairments exhibited more kinetic engagement than people living with dementia [<xref ref-type="bibr" rid="ref52">52</xref>]. Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>] and Klein et al [<xref ref-type="bibr" rid="ref25">25</xref>] found that FIVR reminiscence interventions encouraged conversation and positive participant-caregiver interactions.</p>
        </sec>
        <sec>
          <title>Depression</title>
          <p>Depression was measured using the Center for Epidemiological Studies Depression and the Geriatric Depression Scale (Short Form) in 2 studies [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]. Huang and Yang [<xref ref-type="bibr" rid="ref53">53</xref>] noted that participants experienced significant depression improvements immediately and 3 to 6 months after the intervention. In contrast, Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>] reported no significant influence on depression.</p>
        </sec>
        <sec>
          <title>Loneliness</title>
          <p>One study assessed intervention effects on loneliness using the Three-Item Loneliness Scale, finding no significant outcomes [<xref ref-type="bibr" rid="ref57">57</xref>].</p>
        </sec>
        <sec>
          <title>Fatigue</title>
          <p>One study reported less fatigue in the reminiscence sessions supported by FIVR and photos, compared with the control group with no visual aids [<xref ref-type="bibr" rid="ref59">59</xref>].</p>
        </sec>
      </sec>
      <sec>
        <title>Quality of Life</title>
        <p>Two studies concluded that FIVR reminiscence interventions did not significantly affect participants’ perceived quality of life, as assessed by the European Health Interview Survey–Quality of Life (EUROHIS-QOL) 8-item Index and the Quality of Life in Alzheimer Disease 13-item Scale [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref57">57</xref>].</p>
      </sec>
      <sec>
        <title>Caregivers’ Burdens</title>
        <p>Caregivers’ burdens were examined in 2 studies. Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>] found that the FIVR reminiscence intervention reduced caregivers’ burdens, but Huang and Yang [<xref ref-type="bibr" rid="ref53">53</xref>] reported no significant differences in the caregiver burden scores before and after the intervention.</p>
      </sec>
      <sec>
        <title>Usability and Acceptability</title>
        <p>The usability and acceptability of FIVR in reminiscence sessions were evaluated using various methods such as a self-report questionnaire [<xref ref-type="bibr" rid="ref55">55</xref>], behavior observation and analysis [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>], and interviews [<xref ref-type="bibr" rid="ref58">58</xref>]. Most participants indicated that FIVR reminiscence effectively evoked their past memories and was both enjoyable and acceptable. However, 1 study reported that FIVR triggered unpleasant memories in several participants [<xref ref-type="bibr" rid="ref58">58</xref>].</p>
        <p>Of the 4 studies addressing adverse effects, Saredakis et al [<xref ref-type="bibr" rid="ref56">56</xref>] reported “some” negative symptoms or side effects. In contrast, the other 3 studies found “no simulator sickness” [<xref ref-type="bibr" rid="ref40">40</xref>], “no significant side effects/discomfort” [<xref ref-type="bibr" rid="ref57">57</xref>], and “negligible sickness symptoms” [<xref ref-type="bibr" rid="ref59">59</xref>].</p>
        <p>Four studies included caregivers and family members as participants [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]. Both Coelho et al [<xref ref-type="bibr" rid="ref40">40</xref>] and Webber et al [<xref ref-type="bibr" rid="ref58">58</xref>] observed that caregivers and family members viewed the FIVR reminiscence experience as potentially beneficial and valuable. However, 1 study [<xref ref-type="bibr" rid="ref25">25</xref>] noted that caregivers found the reminiscence intervention impractical in an ambulant daycare setting because of the lack of staff for individual sessions.</p>
      </sec>
      <sec>
        <title>Comparison Between FIVR and Other Technologies</title>
        <p>Three studies compared different effects between the applications of FIVR and other technologies in reminiscence sessions [<xref ref-type="bibr" rid="ref57">57</xref>-<xref ref-type="bibr" rid="ref59">59</xref>]. Two studies found that the use of FIVR and a flat screen for reminiscence did not result in noticeable differences among participants [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>], although participants in the study by Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>] preferred the FIVR experience over a flat screen. Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>] reported that both FIVR and printed photos could elicit the recall of autobiographical memory with no significant difference. However, the participants experienced greater pleasure in FIVR than in printed photos. In addition, Yahara et al [<xref ref-type="bibr" rid="ref60">60</xref>] compared remote and in-person FIVR sessions and found no significant differences in terms of effectiveness.</p>
      </sec>
      <sec>
        <title>Study Limitations</title>
        <p>All selected articles but one discussed their study limitations. Common limitations across multiple studies were (1) small sample size [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], (2) the absence of a control or comparison group [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref56">56</xref>], and (3) participant selection bias [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. Other limitations were related to self-report errors [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], the lack of long-term or follow-up assessment [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>], the unavailability of validated assessment tools for specific components [<xref ref-type="bibr" rid="ref40">40</xref>], being affected by the COVID-19 pandemic [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], exclusion of participants with severe cognitive impairments [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>], and imperfect FIVR contents [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref55">55</xref>].</p>
      </sec>
      <sec>
        <title>Future Research Directions</title>
        <p>The authors advocated for a well-designed study with control or comparison groups, an adequate sample size, and follow-up or long-term assessment for future research on FIVR reminiscence interventions [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref60">60</xref>].</p>
        <p>They also identified an extensive range of future research directions, encompassing 16 directions across 6 aspects:</p>
        <list list-type="order">
          <list-item>
            <p>Caregiver aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Investigating training for family caregivers to safely use FIVR for reminiscence sessions [<xref ref-type="bibr" rid="ref52">52</xref>]</p>
              </list-item>
              <list-item>
                <p>Examining the effects of the caregiver in charge [<xref ref-type="bibr" rid="ref25">25</xref>]</p>
              </list-item>
            </list>
          </list-item>
          <list-item>
            <p>Health and behavioral improvement aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Further investigation of the effects of FIVR reminiscence on psychological or behavioral symptoms, cognitive functions, and quality of life [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref53">53</xref>]</p>
              </list-item>
            </list>
          </list-item>
          <list-item>
            <p>Social or engagement aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Examining the social aspect of FIVR and its application in older adult care settings, at home, or with family members [<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref54">54</xref>]</p>
              </list-item>
              <list-item>
                <p>Examining how to improve participants’ engagement and adherence to the FIVR intervention [<xref ref-type="bibr" rid="ref40">40</xref>]</p>
              </list-item>
              <list-item>
                <p>Exploring how to develop remote options for FIVR reminiscence interventions to promote use among the individual, caregiver, and family members [<xref ref-type="bibr" rid="ref60">60</xref>]</p>
              </list-item>
            </list>
          </list-item>
          <list-item>
            <p>Operation, implementation, or ethical aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Establishing a metric to assure successful operation of the FIVR intervention [<xref ref-type="bibr" rid="ref25">25</xref>]</p>
              </list-item>
              <list-item>
                <p>Investigating the barriers for the FIVR implementation and related solutions [<xref ref-type="bibr" rid="ref40">40</xref>]</p>
              </list-item>
              <list-item>
                <p>Identifying ethical ramifications of applying the FIVR intervention to individuals with severe dementia [<xref ref-type="bibr" rid="ref40">40</xref>]</p>
              </list-item>
            </list>
          </list-item>
          <list-item>
            <p>Technical aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Exploring the possibility of using log data, eye-tracking data, machine learning, and artificial intelligence to assist in the design of future FIVR reminiscence intervention prototype [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]</p>
              </list-item>
              <list-item>
                <p>Understanding the added value of FIVR in reminiscence interventions [<xref ref-type="bibr" rid="ref40">40</xref>]</p>
              </list-item>
              <list-item>
                <p>Comparing FIVR with traditional forms of reminiscence interventions [<xref ref-type="bibr" rid="ref53">53</xref>]</p>
              </list-item>
              <list-item>
                <p>Investigating the method to combine FIVR reminiscence interventions with the digital mapping of media from public sources or family archives [<xref ref-type="bibr" rid="ref55">55</xref>]</p>
              </list-item>
            </list>
          </list-item>
          <list-item>
            <p>Human–FIVR environment interaction aspect</p>
            <list list-type="bullet">
              <list-item>
                <p>Observing participants’ limb movements during the session to analyze their movements in FIVR [<xref ref-type="bibr" rid="ref53">53</xref>]</p>
              </list-item>
              <list-item>
                <p>Investigate how people living with dementia interact with the FIVR environment [<xref ref-type="bibr" rid="ref59">59</xref>]</p>
              </list-item>
              <list-item>
                <p>Exploring how the FIVR environment can create charming experiences with specific therapeutic effects [<xref ref-type="bibr" rid="ref59">59</xref>]</p>
              </list-item>
            </list>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>In total, 11 articles [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref60">60</xref>] detailing empirical studies on FIVR reminiscence interventions in older adults were selected for this review. All but 1 study focused on individuals with cognitive impairments or dementia. The results showed that the intervention enhanced engagement and reduced fatigue. Although some studies reported positive effects of FIVR reminiscence sessions on participants’ anxiety, apathy, depression, cognitive functions, and caregiver burden reduction, the results were not consistent across all studies. Moreover, FIVR showed overall usability and acceptability with manageable side effects among older adults.</p>
      </sec>
      <sec>
        <title>Effectiveness of FIVR-Assisted Reminiscence Interventions in Older Adults</title>
        <p>Overall, the review results demonstrated that FIVR-assisted reminiscence interventions, as a nonpharmacological option, were effective in improving some health- and behavior-related outcomes such as engagement and fatigue in older adults. Their effects on depression, anxiety, and apathy were not consistent. There were no significant impacts on other measures such as cognitive functions or dementia status, quality of life, and loneliness. However, it may be too soon to conclude that FIVR may not help induce further health benefits through reminiscence activities, as only 11 studies with small sample sizes and limited time frames were included in this review. Additional studies are required to provide a clearer understanding of this topic.</p>
      </sec>
      <sec>
        <title>Usability and Acceptability</title>
        <p>Most participants in the selected studies felt that the FIVR technology was acceptable and enjoyable. However, a study reported that reminiscence interventions may induce negative memories leading to undesirable feelings or undesirable health results [<xref ref-type="bibr" rid="ref58">58</xref>], which raised the alarm about the selection of visual content. Otherwise, the side effects of FIVR were deemed manageable, with only a few cases reporting motion sickness. According to Chang et al [<xref ref-type="bibr" rid="ref62">62</xref>], VR motion sickness includes symptoms such as eye fatigue, disorientation, and nausea, which are often caused by viewing dynamic content. The authors contended that motion sickness usually occurred when a person is immersed in moving VR scenes that yields an illusory perception of self-motion but their body is still in a static (standing or sitting) state. Other causes of motion sickness may be related to the fidelity of the VR stimuli and human factors [<xref ref-type="bibr" rid="ref62">62</xref>]. Although human factors such as genetics and brain reactions may not be easy to change, the fidelity of VR stimuli can be improved, for example, by increasing the resolution or realistic sense of the visual content. There are many web-based platforms offering rich VR resources such as YouTube and Google Street Views, which were adopted by some selected studies. However, this type of content may not be ideal considering some quality problems such as distortion, glare, and low resolution. Several studies selected for this review used this content as stimuli but did not discuss quality issues in their articles.</p>
      </sec>
      <sec>
        <title>Impact on Caregivers’ Burden</title>
        <p>Globally, there is a serious shortage in the nursing workforce; consequently, people living with dementia or mild cognitive impairments or other chronic diseases are usually cared for by informal caregivers, most of whom are family members. The care time was approximately 27.1 hours per week per person in 2021 [<xref ref-type="bibr" rid="ref39">39</xref>], which is a burden on caregivers, especially those who provide informal care but still need to work for a living. This burden may be exacerbated as the person experiences further decline in cognitive functions along with an increase in behavioral problems and the loss of independent living. The selected studies revealed that caregivers viewed FIVR-assisted reminiscence as beneficial and valuable for people living with mild cognitive impairments and dementia. The effects of such interventions on anxiety and apathy may potentially lower caregivers’ burden and companion time. Additional functions that link other people with the people living with dementia remotely through web-based platforms can better involve more family members or friends in reminiscence, which also helps reduce caregiving burden. However, as the hardware and the activity need to be set up and a facilitator is often required during the process, the reminiscence intervention may instead become an additional burden to caregivers, especially those serving in institutional care facilities where a nursing staff member provides care to multiple people.</p>
      </sec>
      <sec>
        <title>FIVR Versus Other Technologies</title>
        <p>In the previous section, we outlined the timeline for the different technical aids used in reminiscence interventions. Since the mid-2010s, VR has gradually become a viable option for facilitating the recall of past experiences in older adults. This evolution began with nonimmersive VR [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], displaying the virtual world through an electronic screen such as a tablet, television, or computer screen. Semi-immersive VR emerged later as another option [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>], offering a more realistic experience by using multiple large screens or a VR Cave Automatic Virtual Environment that forms an enclosed or semienclosed environment in which to display VR content. FIVR has been considered more effective in evoking memories and is therefore more favorable for reminiscence compared with other aids, because of its fully immersive features. However, this assumption was not fully supported by evidence from the selected studies. It was noted that the results were mixed when comparing FIVR with other technical aids. For example, Saredakis et al [<xref ref-type="bibr" rid="ref57">57</xref>] and Xu and Wang [<xref ref-type="bibr" rid="ref59">59</xref>] found that participants preferred using FIVR for visual content over a flat screen or printed photos, whereas participants in another study reported that FIVR did not provide richer reminiscence experiences than those from an iPad [<xref ref-type="bibr" rid="ref47">47</xref>]. In addition, FIVR may present some challenges for the participant or caregiver in controlling and manipulating the technology [<xref ref-type="bibr" rid="ref58">58</xref>]. Nevertheless, FIVR is a relatively new technology and its application in reminiscence interventions is still in its infancy. Therefore, it may be too soon to conclude that FIVR is superior or inferior to the other traditional aids. The suitability of using FIVR may depend on the type of reminiscence intervention, content of the visual stimuli, and specific person in the session.</p>
      </sec>
      <sec>
        <title>FIVR for People With Mild Cognitive Impairments and People Living With Dementia</title>
        <p>Most of the selected studies focused on individuals with mild cognitive impairments or people living with dementia, making their results applicable to these groups. Only 1 study compared the FIVR effects between the population with mild cognitive impairment and that living with dementia [<xref ref-type="bibr" rid="ref52">52</xref>]. The results indicated that people living with dementia were more immersed in VR, possibly because the realistic environment captured their attention better than it did for those with mild cognitive impairment. This is important because a higher level of immersion may lead to more emotional engagement, which would trigger unpleasant memories or emotions, resulting in adverse outcomes. Moreover, individuals with mild cognitive impairments displayed greater kinetic engagement during FIVR sessions, potentially owing to better physical health and mobility. However, the exact reasons remain unclear. Notably, there’s a scarcity of studies comparing patients with mild cognitive impairments or dementia with noncognitively impaired groups. Further research comparing multiple user groups, such as young adults, healthy older adults, patients with mild cognitive impairments, and people living with dementia, is essential.</p>
      </sec>
      <sec>
        <title>Types of FIVR Reminiscence Interventions</title>
        <p>Only 1 study specified its intervention type as semistructured simple reminiscence. The other 2 types of reminiscence, life review and life story review, were not examined in the selected studies. Our speculations are as follows: (1) life review and life story review require professionally trained staff, posing challenges for research teams; (2) these approaches might demand more time (≥45 min), and using VR goggles for over 20 minutes could induce negative side effects; and (3) most research teams were led by design or computer science professionals, focusing on developing and testing the FIVR prototype. Life review and life story review are vital for end-of-life care, particularly for patients with cancer [<xref ref-type="bibr" rid="ref15">15</xref>]. Consequently, further research on FIVR-supported life review is critical to address this gap.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The limitations of this literature review are related to the characteristics of the studies and the nature of the scoping review. As noted earlier, the selected studies had some common limitations. First, the sample sizes were relatively small, ranging from 2 to 43 participants (mean 17). Only 4 studies had 20 or more participants. A small sample size has been a common issue in studies involving older adults with cognitive impairment, possibly because of the difficulties in recruitment and retention. Second, most studies were quasi-experiments, case studies, or qualitative research. Only 2 studies used control groups. Third, most studies evaluated the short-term but not the long-term effects of the interventions. Fourth, because most of the studies were conducted by the teams that created the FIVR tools, the study foci were largely on usability aspects but not on health outcomes, although these were also measured.</p>
        <p>We attempted to identify related articles through different databases; however, the number of included studies was small (N=11). Possible reasons were that FIVR was a relatively new technology that took some time to be developed and evaluated in this field and that some studies may have been published in non–English language journals. Furthermore, there may have been publication bias; studies that did not find any significant results may not have been published. In addition, the selected studies used various research designs, sample sizes, and measurements, which presented challenges for a systematic, rigorous review, or meta-analysis.</p>
      </sec>
      <sec>
        <title>Implications</title>
        <sec>
          <title>Additional Future Research Directions</title>
          <p>In addition to the research directions raised in the selected articles, we identified the following topics, based on this scoping review results, to further address current research gaps: (1) evaluating the impacts of FIVR quality in terms of fidelity and resolution on the effectiveness of reminiscence sessions; (2) identifying the most effective types of FIVR content, including events, locations, objects, people, sounds, and music; (3) developing and testing feasible strategies to lower caregiver burden through FIVR reminiscence interventions; (4) evaluating a specific type of FIVR reminiscence (simple reminiscence, life review, or life review therapy); and (5) comparing the effects of FIVR reminiscence on multiple user groups, such as young adults, healthy older adults, people with mild cognitive impairments, and people living with dementia. Attention to these research topics would advance our knowledge in this field.</p>
        </sec>
        <sec>
          <title>Recommendations for Practice</title>
          <sec>
            <title>Overview</title>
            <p>FIVR has become more affordable and accessible over the last decade and therefore could be used in any reminiscence activities led by therapists, certified professionals, caregivers, and family members. It is a relatively safe therapeutic option if developed and implemented appropriately. On the basis of the review results and what we learned from our ongoing pilot studies, we provide a list of recommendations for those who would like to create FIVR stimuli to be used in reminiscence activities:</p>
          </sec>
          <sec>
            <title>FIVR Content</title>
            <p>Content can come from a variety of resources including web-based video sharing platforms such as YouTube and Vimeo, self-produced VR media including photos and videos, and Google Street View images. VR content can be location or event based. These locations can be childhood homes, hometowns, churches, and neighborhoods, whereas events can be weddings, birthday parties, and anniversary ceremonies. The literature suggests that selecting the most familiar places or events or those with pleasurable memories may help maximize positive outcomes. The most recent models of 360° camera allow people to produce high-quality (4K+ resolution) VR photos and videos on their own. Common camera brands include Instra360, GoPro, and Ricoh, with prices ranging from US $200 to US $800 in 2022. To reduce the possibility of motion sickness, we recommend using a fixed camera, which means that the camera is not moving around while taking videos. Once 360° photos and videos are taken, they can be uploaded to YouTube or Vimeo with minimal editing effort. Another type of VR stimulus, computer graphic–based animations or images, is not recommended for public use because it requires well-trained professionals and considerable time to build the content.</p>
          </sec>
          <sec>
            <title>FIVR Device</title>
            <p>We recommend consumer-grade VR goggles for reminiscence interventions because they require minimal technical support and have a less steep learning curve compared with professional goggles. As shown in the selected studies, Oculus was the go-to brand for FIVR reminiscence. The newest model in 2022 is the Oculus Quest 2, which offers its own operating system and can be used independently without connecting to computers or game consoles. It provides easy access to different websites and apps, including YouTube, and VR videos stored in video memory cards.</p>
          </sec>
          <sec>
            <title>Types of Reminiscence Intervention</title>
            <p>Among the 3 types of reminiscence interventions introduced in this paper, simple reminiscence is the least structured and the easiest to carry out, whereas life review and life review therapy may require specific training for the facilitator. Depending on the goals of the intervention and the facilitator’s ability, a decision about the type of intervention to be used should be made collectively by the person and the person’s caregiver, family members, and health care providers for maximal benefit.</p>
          </sec>
          <sec>
            <title>Facilitators</title>
            <p>We support the claim by Molinari [<xref ref-type="bibr" rid="ref9">9</xref>] that reminiscence interventions can be conducted by both laypersons and trained professionals. In addition to providing cues during the activity, the facilitator should be able to set up the device, assist the person with accessing the VR scene, provide surveillance to avoid possible side effects including motion sickness and negative emotions, and evaluate the effectiveness of the intervention.</p>
            <p>It should be noted that users should double-check existing practices or patient safety guidelines before applying these recommendations.</p>
          </sec>
        </sec>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>The growing number of older adults living with dementia or mild cognitive impairments has amplified the crises of caregiver shortage and continuously rising health care costs. We reviewed existing empirical studies that evaluated FIVR reminiscence interventions. The results indicated that such interventions, if delivered appropriately, may help improve the user’s psychological and mental health and potentially decrease the burden on caregivers. The studies also revealed a positive experience with FIVR technology, which most participants found acceptable and enjoyable. On the basis of the literature review, we identified directions for future research and provided recommendations for practice in FIVR reminiscence interventions.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist.</p>
        <media xlink:href="games_v11i1e45539_app1.docx" xlink:title="DOCX File , 84 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Article search and screening process.</p>
        <media xlink:href="games_v11i1e45539_app2.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 24 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Original data and data descriptive summary.</p>
        <media xlink:href="games_v11i1e45539_app3.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 185 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">EUROHIS-QOL</term>
          <def>
            <p>European Health Interview Survey–Quality of Life</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">FIVR</term>
          <def>
            <p>fully immersive virtual reality</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">VR</term>
          <def>
            <p>virtual reality</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <notes>
      <sec>
        <title>Data Availability</title>
        <p>The original data are available in <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref52">52</xref>-<xref ref-type="bibr" rid="ref60">60</xref>].</p>
      </sec>
    </notes>
    <fn-group>
      <fn fn-type="con">
        <p>All authors contributed significantly to this manuscript in terms of conception, research design, data extraction and analysis, and interpretation of the review results. ZL raised the initial research questions, led the review process, critically reviewed the selected articles, and interpreted the results. WW led the article search and screening process and data analysis. ZL and WW drafted the manuscript. WY and JHS edited the technology-related content. CLK and MO edited the sections related to public health issues, the practice of reminiscence therapies or interventions, and the interpretation and implications of the findings.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Demeco</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Zola</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Frizziero</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Martini</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Palumbo</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Foresti</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Buccino</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Costantino</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Immersive virtual reality in post-stroke rehabilitation: a systematic review</article-title>
          <source>Sensors (Basel)</source>
          <year>2023</year>
          <month>02</month>
          <day>03</day>
          <volume>23</volume>
          <issue>3</issue>
          <fpage>1712</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.mdpi.com/resolver?pii=s23031712"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/s23031712</pub-id>
          <pub-id pub-id-type="medline">36772757</pub-id>
          <pub-id pub-id-type="pii">s23031712</pub-id>
          <pub-id pub-id-type="pmcid">PMC9919580</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lasaponara</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Marson</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Doricchi</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Cavallo</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>A scoping review of cognitive training in neurodegenerative diseases via computerized and virtual reality tools: what we know so far</article-title>
          <source>Brain Sci</source>
          <year>2021</year>
          <month>04</month>
          <day>21</day>
          <volume>11</volume>
          <issue>5</issue>
          <fpage>528</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.mdpi.com/resolver?pii=brainsci11050528"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/brainsci11050528</pub-id>
          <pub-id pub-id-type="medline">33919244</pub-id>
          <pub-id pub-id-type="pii">brainsci11050528</pub-id>
          <pub-id pub-id-type="pmcid">PMC8143131</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ozkul</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Guclu-Gunduz</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Yazici</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Atalay Guzel</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Irkec</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Effect of immersive virtual reality on balance, mobility, and fatigue in patients with multiple sclerosis: a single-blinded randomized controlled trial</article-title>
          <source>Eur J Integr Med</source>
          <year>2020</year>
          <month>04</month>
          <volume>35</volume>
          <fpage>101092</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.12345/ijvr.2017.120105"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.eujim.2020.101092</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Brimelow</surname>
              <given-names>RE</given-names>
            </name>
            <name name-style="western">
              <surname>Thangavelu</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Beattie</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Dissanayaka</surname>
              <given-names>NN</given-names>
            </name>
          </person-group>
          <article-title>Feasibility of group-based multiple virtual reality sessions to reduce behavioral and psychological symptoms in persons living in residential aged care</article-title>
          <source>J Am Med Dir Assoc</source>
          <year>2022</year>
          <month>05</month>
          <volume>23</volume>
          <issue>5</issue>
          <fpage>831</fpage>
          <lpage>7.e2</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.12345/jmht.2016.730205"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jamda.2021.07.026</pub-id>
          <pub-id pub-id-type="medline">34454923</pub-id>
          <pub-id pub-id-type="pii">S1525-8610(21)00674-5</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cammisuli</surname>
              <given-names>DM</given-names>
            </name>
            <name name-style="western">
              <surname>Danti</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Bosinelli</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Cipriani</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Non-pharmacological interventions for people with Alzheimer's Disease: a critical review of the scientific literature from the last ten years</article-title>
          <source>Eur Geriatr Med</source>
          <year>2016</year>
          <month>02</month>
          <volume>7</volume>
          <issue>1</issue>
          <fpage>57</fpage>
          <lpage>64</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1016/j.eurger.2016.01.002"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.eurger.2016.01.002</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Coleman</surname>
              <given-names>PG</given-names>
            </name>
          </person-group>
          <article-title>Uses of reminiscence: functions and benefits</article-title>
          <source>Aging Ment Health</source>
          <year>2005</year>
          <month>07</month>
          <volume>9</volume>
          <issue>4</issue>
          <fpage>291</fpage>
          <lpage>4</lpage>
          <pub-id pub-id-type="doi">10.1080/13607860500169641</pub-id>
          <pub-id pub-id-type="medline">16019283</pub-id>
          <pub-id pub-id-type="pii">G68401V61328608P</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="web">
          <article-title>Reminiscence</article-title>
          <source>Merriam-Webster</source>
          <access-date>2022-12-15</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.merriam-webster.com/dictionary/reminiscence">https://www.merriam-webster.com/dictionary/reminiscence</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Butler</surname>
              <given-names>RN</given-names>
            </name>
          </person-group>
          <article-title>The life review: an interpretation of reminiscence in the aged</article-title>
          <source>Psychiatry</source>
          <year>1963</year>
          <month>02</month>
          <volume>26</volume>
          <fpage>65</fpage>
          <lpage>76</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1080/00332747.1963.11023339"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/00332747.1963.11023339</pub-id>
          <pub-id pub-id-type="medline">14017386</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Molinari</surname>
              <given-names>V</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Duffy</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Using reminiscence and life review as natural therapeutic strategies in group therapy</article-title>
          <source>Handbook of Counseling and Psychotherapy With Older Adults</source>
          <year>1999</year>
          <publisher-loc>Hoboken, NJ</publisher-loc>
          <publisher-name>John Wiley &#38; Sons, Inc</publisher-name>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="web">
          <article-title>Licensed mental health professionals in Texas: a fact sheet for consumers</article-title>
          <source>Texas Department of State Health Services</source>
          <access-date>2023-09-22</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.hhs.texas.gov/sites/default/files/documents/doing-business-with-hhs/licensing-credentialing-regulation/csot/lmh-fact.pdf">https://www.hhs.texas.gov/sites/default/files/documents/doing-business-with-hhs/licensing-credentialing-regulation/csot/lmh-fact.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pinquart</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Forstmeier</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Effects of reminiscence interventions on psychosocial outcomes: a meta-analysis</article-title>
          <source>Aging Ment Health</source>
          <year>2012</year>
          <volume>16</volume>
          <issue>5</issue>
          <fpage>541</fpage>
          <lpage>58</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.5167/uzh-70978"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/13607863.2011.651434</pub-id>
          <pub-id pub-id-type="medline">22304736</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Woods</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>O'Philbin</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Farrell</surname>
              <given-names>EM</given-names>
            </name>
            <name name-style="western">
              <surname>Spector</surname>
              <given-names>AE</given-names>
            </name>
            <name name-style="western">
              <surname>Orrell</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Reminiscence therapy for dementia</article-title>
          <source>Cochrane Database Syst Rev</source>
          <year>2018</year>
          <month>03</month>
          <day>01</day>
          <volume>3</volume>
          <issue>3</issue>
          <fpage>CD001120</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/29493789"/>
          </comment>
          <pub-id pub-id-type="doi">10.1002/14651858.CD001120.pub3</pub-id>
          <pub-id pub-id-type="medline">29493789</pub-id>
          <pub-id pub-id-type="pmcid">PMC6494367</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Thomas</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Sezgin</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Effectiveness of reminiscence therapy in reducing agitation and depression and improving quality of life and cognition in long-term care residents with dementia: a systematic review and meta-analysis</article-title>
          <source>Geriatr Nurs</source>
          <year>2021</year>
          <volume>42</volume>
          <issue>6</issue>
          <fpage>1497</fpage>
          <lpage>506</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1016/j.gerinurse.2021.10.014"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.gerinurse.2021.10.014</pub-id>
          <pub-id pub-id-type="medline">34735996</pub-id>
          <pub-id pub-id-type="pii">S0197-4572(21)00334-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chochinov</surname>
              <given-names>HM</given-names>
            </name>
            <name name-style="western">
              <surname>Hack</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Hassard</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Kristjanson</surname>
              <given-names>LJ</given-names>
            </name>
            <name name-style="western">
              <surname>McClement</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Harlos</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Dignity therapy: a novel psychotherapeutic intervention for patients near the end of life</article-title>
          <source>J Clin Oncol</source>
          <year>2005</year>
          <month>08</month>
          <day>20</day>
          <volume>23</volume>
          <issue>24</issue>
          <fpage>5520</fpage>
          <lpage>5</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1200/JCO.2005.08.391"/>
          </comment>
          <pub-id pub-id-type="doi">10.1200/JCO.2005.08.391</pub-id>
          <pub-id pub-id-type="medline">16110012</pub-id>
          <pub-id pub-id-type="pii">23/24/5520</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sun</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Zhang</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Dong</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Wu</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>The efficacy of reminiscence therapy in cancer-related symptom management: a systematic review and meta-analysis</article-title>
          <source>Integr Cancer Ther</source>
          <year>2023</year>
          <volume>22</volume>
          <fpage>15347354221147499</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://journals.sagepub.com/doi/10.1177/15347354221147499?url_ver=Z39.88-2003&#38;rfr_id=ori:rid:crossref.org&#38;rfr_dat=cr_pub  0pubmed"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/15347354221147499</pub-id>
          <pub-id pub-id-type="medline">36625232</pub-id>
          <pub-id pub-id-type="pmcid">PMC9834792</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Westphal</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Dingjan</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Attoe</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>What can low and high technologies do for late-life mental disorders?</article-title>
          <source>Curr Opin Psychiatry</source>
          <year>2010</year>
          <month>11</month>
          <volume>23</volume>
          <issue>6</issue>
          <fpage>510</fpage>
          <lpage>5</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1097/YCO.0b013e32833d74d4"/>
          </comment>
          <pub-id pub-id-type="doi">10.1097/YCO.0b013e32833d74d4</pub-id>
          <pub-id pub-id-type="medline">20717039</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Shin</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Sok</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Effects of reminiscence therapy on quality of life and life satisfaction of the elderly in the community: a systematic review</article-title>
          <source>BMC Geriatr</source>
          <year>2023</year>
          <month>07</month>
          <day>10</day>
          <volume>23</volume>
          <issue>1</issue>
          <fpage>420</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-04001-1"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12877-023-04001-1</pub-id>
          <pub-id pub-id-type="medline">37430198</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12877-023-04001-1</pub-id>
          <pub-id pub-id-type="pmcid">PMC10332080</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lazar</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Thompson</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Demiris</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>A systematic review of the use of technology for reminiscence therapy</article-title>
          <source>Health Educ Behav</source>
          <year>2014</year>
          <month>10</month>
          <volume>41</volume>
          <issue>1 Suppl</issue>
          <fpage>51S</fpage>
          <lpage>61S</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25274711"/>
          </comment>
          <pub-id pub-id-type="doi">10.1177/1090198114537067</pub-id>
          <pub-id pub-id-type="medline">25274711</pub-id>
          <pub-id pub-id-type="pii">1090198114537067</pub-id>
          <pub-id pub-id-type="pmcid">PMC4844844</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Glynn</surname>
              <given-names>NJ</given-names>
            </name>
          </person-group>
          <article-title>The music therapy assessment tool in Alzheimer's patients</article-title>
          <source>J Gerontol Nurs</source>
          <year>1992</year>
          <month>01</month>
          <volume>18</volume>
          <issue>1</issue>
          <fpage>3</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.3928/0098-9134-19920101-03"/>
          </comment>
          <pub-id pub-id-type="doi">10.3928/0098-9134-19920101-03</pub-id>
          <pub-id pub-id-type="medline">1740613</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Moss</surname>
              <given-names>SE</given-names>
            </name>
            <name name-style="western">
              <surname>Polignano</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>White</surname>
              <given-names>CL</given-names>
            </name>
            <name name-style="western">
              <surname>Minichiello</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Sunderland</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Reminiscence group activities and discourse interaction in Alzheimer's disease</article-title>
          <source>J Gerontol Nurs</source>
          <year>2002</year>
          <month>08</month>
          <volume>28</volume>
          <issue>8</issue>
          <fpage>36</fpage>
          <lpage>44</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.3928/0098-9134-20020801-09"/>
          </comment>
          <pub-id pub-id-type="doi">10.3928/0098-9134-20020801-09</pub-id>
          <pub-id pub-id-type="medline">12219552</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Siriaraya</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Ang</surname>
              <given-names>CS</given-names>
            </name>
          </person-group>
          <article-title>Recreating living experiences from past memories through virtual worlds for people with dementia</article-title>
          <source>Proceedings of the SIGCHI Conference on Human Factors in Computing Systems</source>
          <year>2014</year>
          <month>04</month>
          <conf-name>CHI '14: CHI Conference on Human Factors in Computing Systems</conf-name>
          <conf-date>April 26-May 1, 2014</conf-date>
          <conf-loc>Toronto, ON</conf-loc>
          <pub-id pub-id-type="doi">10.1145/2556288.2557035</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kuwahara</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Abe</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Yasuda</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Kuwabara</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>Networked reminiscence therapy for individuals with dementia by using photo and video sharing</article-title>
          <source>Proceedings of the 8th international ACM SIGACCESS conference on Computers and accessibility</source>
          <year>2006</year>
          <month>10</month>
          <conf-name>ASSETS06: The 8th International ACM SIGACCESS Conference on Computers and Accessibility</conf-name>
          <conf-date>October 23-25, 2006</conf-date>
          <conf-loc>Portland, OR</conf-loc>
          <pub-id pub-id-type="doi">10.1145/1168987.1169010</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chapoulie</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Guerchouche</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Petit</surname>
              <given-names>P-D</given-names>
            </name>
            <name name-style="western">
              <surname>Chaurasia</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Robert</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Drettakis</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Reminiscence therapy using image-based rendering in VR</article-title>
          <source>Proceedings of the 2014 IEEE Virtual Reality (VR)</source>
          <year>2014</year>
          <conf-name>2014 IEEE Virtual Reality (VR)</conf-name>
          <conf-date>March 29-April 2, 2014</conf-date>
          <conf-loc>Minneapolis, MN</conf-loc>
          <pub-id pub-id-type="doi">10.1109/vr.2014.6802049</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Benoit</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Guerchouche</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Petit</surname>
              <given-names>P-D</given-names>
            </name>
            <name name-style="western">
              <surname>Chapoulie</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Manera</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Chaurasia</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Drettakis</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Robert</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Is it possible to use highly realistic virtual reality in the elderly? A feasibility study with image-based rendering</article-title>
          <source>Neuropsychiatr Dis Treat</source>
          <year>2015</year>
          <month>03</month>
          <volume>11</volume>
          <fpage>557</fpage>
          <lpage>63</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25834437"/>
          </comment>
          <pub-id pub-id-type="doi">10.2147/NDT.S73179</pub-id>
          <pub-id pub-id-type="medline">25834437</pub-id>
          <pub-id pub-id-type="pii">ndt-11-557</pub-id>
          <pub-id pub-id-type="pmcid">PMC4357614</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Klein</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Uhlig</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Will</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>The touch and feel of the past—using haptic and VR artefacts to enrich reminiscence therapy for people with dementia</article-title>
          <source>Technologies</source>
          <year>2018</year>
          <month>11</month>
          <day>13</day>
          <volume>6</volume>
          <issue>4</issue>
          <fpage>104</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.3390/technologies6040104"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/technologies6040104</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cuevas</surname>
              <given-names>PE</given-names>
            </name>
            <name name-style="western">
              <surname>Davidson</surname>
              <given-names>PM</given-names>
            </name>
            <name name-style="western">
              <surname>Mejilla</surname>
              <given-names>JL</given-names>
            </name>
            <name name-style="western">
              <surname>Rodney</surname>
              <given-names>TW</given-names>
            </name>
          </person-group>
          <article-title>Reminiscence therapy for older adults with Alzheimer's disease: a literature review</article-title>
          <source>Int J Ment Health Nurs</source>
          <year>2020</year>
          <month>06</month>
          <volume>29</volume>
          <issue>3</issue>
          <fpage>364</fpage>
          <lpage>71</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1111/inm.12692"/>
          </comment>
          <pub-id pub-id-type="doi">10.1111/inm.12692</pub-id>
          <pub-id pub-id-type="medline">31984570</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Gowans</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Campbell</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Alm</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Dye</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Astell</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ellis</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Designing a multimedia conversation aid for reminiscence therapy in dementia care environments</article-title>
          <source>Proceedings of the CHI '04 Extended Abstracts on Human Factors in Computing Systems</source>
          <year>2004</year>
          <conf-name>CHI04: CHI 2004 Conference on Human Factors in Computing Systems</conf-name>
          <conf-date>April 24-29, 2004</conf-date>
          <conf-loc>Vienna, Austria</conf-loc>
          <pub-id pub-id-type="doi">10.1145/985921.985943</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cruz-Neira</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Sandin</surname>
              <given-names>DJ</given-names>
            </name>
            <name name-style="western">
              <surname>DeFanti</surname>
              <given-names>TA</given-names>
            </name>
          </person-group>
          <article-title>Surround-screen projection-based virtual reality: the design and implementation of the CAVE</article-title>
          <source>Proceedings of the 20th annual conference on Computer graphics and interactive technique</source>
          <year>1993</year>
          <conf-name>SIGGRAPH93: 20th Annual Conference and Exhibition on Computer Graphics and Interactive Technique</conf-name>
          <conf-date>August 2-6, 1993</conf-date>
          <conf-loc>Anaheim, CA</conf-loc>
          <pub-id pub-id-type="doi">10.1145/166117.166134</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Logan</surname>
              <given-names>AI</given-names>
            </name>
          </person-group>
          <article-title>Training beyond reality</article-title>
          <source>IFAC Proc Vol</source>
          <year>1998</year>
          <month>10</month>
          <volume>31</volume>
          <issue>33</issue>
          <fpage>183</fpage>
          <lpage>9</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1016/S1474-6670(17)38407-0"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/s1474-6670(17)38407-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>D'Cunha</surname>
              <given-names>NM</given-names>
            </name>
            <name name-style="western">
              <surname>Nguyen</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Naumovski</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>McKune</surname>
              <given-names>AJ</given-names>
            </name>
            <name name-style="western">
              <surname>Kellett</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Georgousopoulou</surname>
              <given-names>EN</given-names>
            </name>
            <name name-style="western">
              <surname>Frost</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Isbel</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>A mini-review of virtual reality-based interventions to promote well-being for people living with dementia and mild cognitive impairment</article-title>
          <source>Gerontology</source>
          <year>2019</year>
          <volume>65</volume>
          <issue>4</issue>
          <fpage>430</fpage>
          <lpage>40</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1159/000500040"/>
          </comment>
          <pub-id pub-id-type="doi">10.1159/000500040</pub-id>
          <pub-id pub-id-type="medline">31108489</pub-id>
          <pub-id pub-id-type="pii">000500040</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sutherland</surname>
              <given-names>IE</given-names>
            </name>
          </person-group>
          <article-title>A head-mounted three dimensional display</article-title>
          <source>Proceedings of the December 9-11, 1968, Fall Joint Computer Conference, Part I</source>
          <year>1968</year>
          <conf-name>AFIPS '68 (Fall, part I)</conf-name>
          <conf-date>December 9-11, 1968</conf-date>
          <conf-loc>San Francisco, CA</conf-loc>
          <pub-id pub-id-type="doi">10.1145/1476589.1476686</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Renganayagalu</surname>
              <given-names>SK</given-names>
            </name>
            <name name-style="western">
              <surname>Mallam</surname>
              <given-names>SC</given-names>
            </name>
            <name name-style="western">
              <surname>Nazir</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Effectiveness of VR head mounted displays in professional training: a systematic review</article-title>
          <source>Technol Knowl Learn</source>
          <year>2021</year>
          <month>01</month>
          <day>01</day>
          <volume>26</volume>
          <fpage>999</fpage>
          <lpage>1041</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1007/s10758-020-09489-9"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s10758-020-09489-9</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Son</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Ross</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Mendoza-Tirado</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>LJ</given-names>
            </name>
          </person-group>
          <article-title>Virtual reality in clinical practice and research: viewpoint on novel applications for nursing</article-title>
          <source>JMIR Nurs</source>
          <year>2022</year>
          <month>03</month>
          <day>16</day>
          <volume>5</volume>
          <issue>1</issue>
          <fpage>e34036</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://nursing.jmir.org/2022/1/e34036/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/34036</pub-id>
          <pub-id pub-id-type="medline">35293870</pub-id>
          <pub-id pub-id-type="pii">v5i1e34036</pub-id>
          <pub-id pub-id-type="pmcid">PMC8968556</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lange</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Koenig</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>C-Y</given-names>
            </name>
            <name name-style="western">
              <surname>McConnell</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Suma</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Bolas</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Rizzo</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Designing informed game-based rehabilitation tasks leveraging advances in virtual reality</article-title>
          <source>Disabil Rehabil</source>
          <year>2012</year>
          <month>04</month>
          <day>12</day>
          <volume>34</volume>
          <issue>22</issue>
          <fpage>1863</fpage>
          <lpage>70</lpage>
          <pub-id pub-id-type="doi">10.3109/09638288.2012.670029</pub-id>
          <pub-id pub-id-type="medline">22494437</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Radianti</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Majchrzak</surname>
              <given-names>TA</given-names>
            </name>
            <name name-style="western">
              <surname>Fromm</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Wohlgenannt</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
          <article-title>A systematic review of immersive virtual reality applications for higher education: design elements, lessons learned, and research agenda</article-title>
          <source>Comput Educ</source>
          <year>2020</year>
          <month>04</month>
          <volume>147</volume>
          <fpage>103778</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1016/j.compedu.2019.103778"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.compedu.2019.103778</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chittaro</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Buttussi</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>Assessing knowledge retention of an immersive serious game vs. a traditional education method in aviation safety</article-title>
          <source>IEEE Trans Vis Comput Graph</source>
          <year>2015</year>
          <month>04</month>
          <day>18</day>
          <volume>21</volume>
          <issue>4</issue>
          <fpage>529</fpage>
          <lpage>38</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1109/TVCG.2015.2391853"/>
          </comment>
          <pub-id pub-id-type="doi">10.1109/TVCG.2015.2391853</pub-id>
          <pub-id pub-id-type="medline">26357103</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lu</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Florez-Arango</surname>
              <given-names>JF</given-names>
            </name>
            <name name-style="western">
              <surname>Seo</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Hamilton</surname>
              <given-names>DK</given-names>
            </name>
            <name name-style="western">
              <surname>Wells-Beede</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>A framework to develop an immersive virtual reality simulation tool for postpartum hemorrhage management nurse training</article-title>
          <source>Nurs Educ Perspect</source>
          <year>2023</year>
          <month>03</month>
          <day>08</day>
          <comment>(forthcoming)<ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1097/01.NEP.0000000000001112"/></comment>
          <pub-id pub-id-type="doi">10.1097/01.NEP.0000000000001112</pub-id>
          <pub-id pub-id-type="medline">36881514</pub-id>
          <pub-id pub-id-type="pii">00024776-990000000-00106</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rajan</surname>
              <given-names>KB</given-names>
            </name>
            <name name-style="western">
              <surname>Weuve</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Barnes</surname>
              <given-names>LL</given-names>
            </name>
            <name name-style="western">
              <surname>McAninch</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>RS</given-names>
            </name>
            <name name-style="western">
              <surname>Evans</surname>
              <given-names>DA</given-names>
            </name>
          </person-group>
          <article-title>Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)</article-title>
          <source>Alzheimers Dement</source>
          <year>2021</year>
          <month>12</month>
          <volume>17</volume>
          <issue>12</issue>
          <fpage>1966</fpage>
          <lpage>75</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/34043283"/>
          </comment>
          <pub-id pub-id-type="doi">10.1002/alz.12362</pub-id>
          <pub-id pub-id-type="medline">34043283</pub-id>
          <pub-id pub-id-type="pmcid">PMC9013315</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="web">
          <article-title>Alzheimer’s disease facts and figures</article-title>
          <source>Alzheimer's Association</source>
          <access-date>2022-12-15</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.alz.org/alzheimers-dementia/facts-figures#:~:text=Over%2011%20million%20Americans%20provide,1%20in%2010%20for%20men">https://www.alz.org/alzheimers-dementia/facts-figures#:~:text=Over%2011%20million%20Americans%20provide,1%20in%2010%20for%20men</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Coelho</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Marques</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Moreira</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Soares</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Portugal</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Marques</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Ferreira</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>Martins</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Fernandes</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Promoting reminiscences with virtual reality headsets: a pilot study with people with dementia</article-title>
          <source>Int J Environ Res Public Health</source>
          <year>2020</year>
          <month>12</month>
          <day>12</day>
          <volume>17</volume>
          <issue>24</issue>
          <fpage>9301</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.mdpi.com/resolver?pii=ijerph17249301"/>
          </comment>
          <pub-id pub-id-type="doi">10.3390/ijerph17249301</pub-id>
          <pub-id pub-id-type="medline">33322679</pub-id>
          <pub-id pub-id-type="pii">ijerph17249301</pub-id>
          <pub-id pub-id-type="pmcid">PMC7763810</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kales</surname>
              <given-names>HC</given-names>
            </name>
            <name name-style="western">
              <surname>Gitlin</surname>
              <given-names>LN</given-names>
            </name>
            <name name-style="western">
              <surname>Lyketsos</surname>
              <given-names>CG</given-names>
            </name>
          </person-group>
          <article-title>Assessment and management of behavioral and psychological symptoms of dementia</article-title>
          <source>BMJ</source>
          <year>2015</year>
          <month>03</month>
          <day>02</day>
          <volume>350</volume>
          <fpage>h369</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/25731881"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/bmj.h369</pub-id>
          <pub-id pub-id-type="medline">25731881</pub-id>
          <pub-id pub-id-type="pmcid">PMC4707529</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Desai</surname>
              <given-names>AK</given-names>
            </name>
            <name name-style="western">
              <surname>Grossberg</surname>
              <given-names>GT</given-names>
            </name>
            <name name-style="western">
              <surname>Sheth</surname>
              <given-names>DN</given-names>
            </name>
          </person-group>
          <article-title>Activities of daily living in patients with dementia: clinical relevance, methods of assessment and effects of treatment</article-title>
          <source>CNS Drugs</source>
          <year>2004</year>
          <volume>18</volume>
          <issue>13</issue>
          <fpage>853</fpage>
          <lpage>75</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.2165/00023210-200418130-00003"/>
          </comment>
          <pub-id pub-id-type="doi">10.2165/00023210-200418130-00003</pub-id>
          <pub-id pub-id-type="medline">15521790</pub-id>
          <pub-id pub-id-type="pii">18133</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="web">
          <article-title>Dementia: a public health priority</article-title>
          <source>World Health Organization</source>
          <year>2012</year>
          <month>08</month>
          <day>24</day>
          <access-date>2022-12-15</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.who.int/publications/i/item/dementia-a-public-health-priority">https://www.who.int/publications/i/item/dementia-a-public-health-priority</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Abraha</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Rimland</surname>
              <given-names>JM</given-names>
            </name>
            <name name-style="western">
              <surname>Trotta</surname>
              <given-names>FM</given-names>
            </name>
            <name name-style="western">
              <surname>Dell'Aquila</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Cruz-Jentoft</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Petrovic</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Gudmundsson</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Soiza</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>O'Mahony</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Guaita</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Cherubini</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series</article-title>
          <source>BMJ Open</source>
          <year>2017</year>
          <month>03</month>
          <day>16</day>
          <volume>7</volume>
          <issue>3</issue>
          <fpage>e012759</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmjopen.bmj.com/lookup/pmidlookup?view=long&#38;pmid=28302633"/>
          </comment>
          <pub-id pub-id-type="doi">10.1136/bmjopen-2016-012759</pub-id>
          <pub-id pub-id-type="medline">28302633</pub-id>
          <pub-id pub-id-type="pii">bmjopen-2016-012759</pub-id>
          <pub-id pub-id-type="pmcid">PMC5372076</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Magierski</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Sobow</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Schwertner</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Religa</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Pharmacotherapy of behavioral and psychological symptoms of dementia: state of the art and future progress</article-title>
          <source>Front Pharmacol</source>
          <year>2020</year>
          <volume>11</volume>
          <fpage>1168</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/32848775"/>
          </comment>
          <pub-id pub-id-type="doi">10.3389/fphar.2020.01168</pub-id>
          <pub-id pub-id-type="medline">32848775</pub-id>
          <pub-id pub-id-type="pmcid">PMC7413102</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>H-C</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>Y-T</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>P-Y</given-names>
            </name>
            <name name-style="western">
              <surname>Huey-Lan Hu</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Kuo</surname>
              <given-names>Y-L</given-names>
            </name>
            <name name-style="western">
              <surname>Chiu</surname>
              <given-names>H-Y</given-names>
            </name>
          </person-group>
          <article-title>Reminiscence therapy improves cognitive functions and reduces depressive symptoms in elderly people with dementia: a meta-analysis of randomized controlled trials</article-title>
          <source>J Am Med Dir Assoc</source>
          <year>2015</year>
          <month>12</month>
          <volume>16</volume>
          <issue>12</issue>
          <fpage>1087</fpage>
          <lpage>94</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1016/j.jamda.2015.07.010"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jamda.2015.07.010</pub-id>
          <pub-id pub-id-type="medline">26341034</pub-id>
          <pub-id pub-id-type="pii">S1525-8610(15)00489-2</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Lök</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Bademli</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Selçuk-Tosun</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>The effect of reminiscence therapy on cognitive functions, depression, and quality of life in Alzheimer patients: randomized controlled trial</article-title>
          <source>Int J Geriatr Psychiatry</source>
          <year>2019</year>
          <month>01</month>
          <volume>34</volume>
          <issue>1</issue>
          <fpage>47</fpage>
          <lpage>53</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1002/gps.4980"/>
          </comment>
          <pub-id pub-id-type="doi">10.1002/gps.4980</pub-id>
          <pub-id pub-id-type="medline">30246408</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ingersoll-Dayton</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Kropf</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Campbell</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Parker</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>A systematic review of dyadic approaches to reminiscence and life review among older adults</article-title>
          <source>Aging Ment Health</source>
          <year>2019</year>
          <month>09</month>
          <volume>23</volume>
          <issue>9</issue>
          <fpage>1074</fpage>
          <lpage>85</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1080/13607863.2018.1555696"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/13607863.2018.1555696</pub-id>
          <pub-id pub-id-type="medline">30596457</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="web">
          <article-title>Welcome to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) website!</article-title>
          <source>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</source>
          <access-date>2022-12-15</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://prisma-statement.org">https://prisma-statement.org</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tricco</surname>
              <given-names>AC</given-names>
            </name>
            <name name-style="western">
              <surname>Lillie</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Zarin</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>O'Brien</surname>
              <given-names>KK</given-names>
            </name>
            <name name-style="western">
              <surname>Colquhoun</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Levac</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Moher</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Peters</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Horsley</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Weeks</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Hempel</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Akl</surname>
              <given-names>EA</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>McGowan</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Stewart</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Hartling</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Aldcroft</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Wilson</surname>
              <given-names>MG</given-names>
            </name>
            <name name-style="western">
              <surname>Garritty</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Lewin</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Godfrey</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Macdonald</surname>
              <given-names>MT</given-names>
            </name>
            <name name-style="western">
              <surname>Langlois</surname>
              <given-names>EV</given-names>
            </name>
            <name name-style="western">
              <surname>Soares-Weiser</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Moriarty</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Clifford</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Tunçalp</surname>
              <given-names>Ö</given-names>
            </name>
            <name name-style="western">
              <surname>Straus</surname>
              <given-names>SE</given-names>
            </name>
          </person-group>
          <article-title>PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation</article-title>
          <source>Ann Intern Med</source>
          <year>2018</year>
          <month>10</month>
          <day>02</day>
          <volume>169</volume>
          <issue>7</issue>
          <fpage>467</fpage>
          <lpage>73</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.acpjournals.org/doi/abs/10.7326/M18-0850?url_ver=Z39.88-2003&#38;rfr_id=ori:rid:crossref.org&#38;rfr_dat=cr_pub  0pubmed"/>
          </comment>
          <pub-id pub-id-type="doi">10.7326/M18-0850</pub-id>
          <pub-id pub-id-type="medline">30178033</pub-id>
          <pub-id pub-id-type="pii">2700389</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Munn</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Peters</surname>
              <given-names>MD</given-names>
            </name>
            <name name-style="western">
              <surname>Stern</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Tufanaru</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>McArthur</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Aromataris</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach</article-title>
          <source>BMC Med Res Methodol</source>
          <year>2018</year>
          <month>11</month>
          <day>19</day>
          <volume>18</volume>
          <issue>1</issue>
          <fpage>143</fpage>
          <lpage>7</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-018-0611-x"/>
          </comment>
          <pub-id pub-id-type="doi">10.1186/s12874-018-0611-x</pub-id>
          <pub-id pub-id-type="medline">30453902</pub-id>
          <pub-id pub-id-type="pii">10.1186/s12874-018-0611-x</pub-id>
          <pub-id pub-id-type="pmcid">PMC6245623</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Afifi</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Collins</surname>
              <given-names>NL</given-names>
            </name>
            <name name-style="western">
              <surname>Rand</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Fujiwara</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Mazur</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Otmar</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Dunbar</surname>
              <given-names>NE</given-names>
            </name>
            <name name-style="western">
              <surname>Harrison</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Logsdon</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <article-title>Testing the feasibility of virtual reality with older adults with cognitive impairments and their family members who live at a distance</article-title>
          <source>Innov Aging</source>
          <year>2021</year>
          <volume>5</volume>
          <issue>2</issue>
          <fpage>igab014</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/34632105"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/geroni/igab014</pub-id>
          <pub-id pub-id-type="medline">34632105</pub-id>
          <pub-id pub-id-type="pii">igab014</pub-id>
          <pub-id pub-id-type="pmcid">PMC8494141</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Baker</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Kelly</surname>
              <given-names>RM</given-names>
            </name>
            <name name-style="western">
              <surname>Waycott</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Carrasco</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Bell</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Joukhadar</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Hoang</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Ozanne</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Vetere</surname>
              <given-names>F</given-names>
            </name>
          </person-group>
          <article-title>School's back: scaffolding reminiscence in social virtual reality with older adults</article-title>
          <source>Proc ACM Hum Comput Interact</source>
          <year>2021</year>
          <month>01</month>
          <day>05</day>
          <volume>4</volume>
          <issue>CSCW3</issue>
          <fpage>1</fpage>
          <lpage>25</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1145/3434176"/>
          </comment>
          <pub-id pub-id-type="doi">10.1145/3434176</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>L-C</given-names>
            </name>
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>Y-H</given-names>
            </name>
          </person-group>
          <article-title>The long-term effects of immersive virtual reality reminiscence in people with dementia: longitudinal observational study</article-title>
          <source>JMIR Serious Games</source>
          <year>2022</year>
          <month>07</month>
          <day>25</day>
          <volume>10</volume>
          <issue>3</issue>
          <fpage>e36720</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://games.jmir.org/2022/3/e36720/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/36720</pub-id>
          <pub-id pub-id-type="medline">35877169</pub-id>
          <pub-id pub-id-type="pii">v10i3e36720</pub-id>
          <pub-id pub-id-type="pmcid">PMC9361147</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Niki</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Yahara</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Inagaki</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Takahashi</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Watanabe</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Okuda</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Ueda</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Iwai</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Sato</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Ito</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Immersive virtual reality reminiscence reduces anxiety in the oldest-old without causing serious side effects: a single-center, pilot, and randomized crossover study</article-title>
          <source>Front Hum Neurosci</source>
          <year>2020</year>
          <volume>14</volume>
          <fpage>598161</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://europepmc.org/abstract/MED/33536887"/>
          </comment>
          <pub-id pub-id-type="doi">10.3389/fnhum.2020.598161</pub-id>
          <pub-id pub-id-type="medline">33536887</pub-id>
          <pub-id pub-id-type="pmcid">PMC7849024</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Saredakis</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Keage</surname>
              <given-names>HA</given-names>
            </name>
            <name name-style="western">
              <surname>Corlis</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Loetscher</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Using virtual reality to improve apathy in residential aged care: mixed methods study</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>06</month>
          <day>26</day>
          <volume>22</volume>
          <issue>6</issue>
          <fpage>e17632</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/6/e17632/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/17632</pub-id>
          <pub-id pub-id-type="medline">32469314</pub-id>
          <pub-id pub-id-type="pii">v22i6e17632</pub-id>
          <pub-id pub-id-type="pmcid">PMC7380990</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Saredakis</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Keage</surname>
              <given-names>HA</given-names>
            </name>
            <name name-style="western">
              <surname>Corlis</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ghezzi</surname>
              <given-names>ES</given-names>
            </name>
            <name name-style="western">
              <surname>Loffler</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Loetscher</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>The effect of reminiscence therapy using virtual reality on apathy in residential aged care: multisite nonrandomized controlled trial</article-title>
          <source>J Med Internet Res</source>
          <year>2021</year>
          <month>09</month>
          <day>20</day>
          <volume>23</volume>
          <issue>9</issue>
          <fpage>e29210</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2021/9/e29210/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/29210</pub-id>
          <pub-id pub-id-type="medline">34542418</pub-id>
          <pub-id pub-id-type="pii">v23i9e29210</pub-id>
          <pub-id pub-id-type="pmcid">PMC8491119</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Webber</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Baker</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Waycott</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Virtual visits: reminiscence in residential aged care with digital mapping technologies</article-title>
          <source>Australas J Ageing</source>
          <year>2021</year>
          <month>09</month>
          <volume>40</volume>
          <issue>3</issue>
          <fpage>293</fpage>
          <lpage>300</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1111/ajag.12902"/>
          </comment>
          <pub-id pub-id-type="doi">10.1111/ajag.12902</pub-id>
          <pub-id pub-id-type="medline">33538405</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Efficacy of VR-based reminiscence therapy in improving autobiographical memory for Chinese patients with AD</article-title>
          <source>Proceedings of the AHFE 2020 Virtual Conference on Ergonomics in Design</source>
          <year>2020</year>
          <conf-name>AHFE 2020 Virtual Conference on Ergonomics in Design</conf-name>
          <conf-date>July 16-20, 2020</conf-date>
          <conf-loc>Virtual, USA</conf-loc>
          <pub-id pub-id-type="doi">10.1007/978-3-030-51038-1_47</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yahara</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Niki</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Ueno</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Okamoto</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Okuda</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Tanaka</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Naito</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Ishii</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Ueda</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ito</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Remote reminiscence using immersive virtual reality may be efficacious for reducing anxiety in patients with mild cognitive impairment even in COVID-19 pandemic: a case report</article-title>
          <source>Biol Pharm Bull</source>
          <year>2021</year>
          <volume>44</volume>
          <issue>7</issue>
          <fpage>1019</fpage>
          <lpage>23</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.doi.org/10.1248/bpb.b21-00052"/>
          </comment>
          <pub-id pub-id-type="doi">10.1248/bpb.b21-00052</pub-id>
          <pub-id pub-id-type="medline">34193684</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="web">
          <article-title>Apathy</article-title>
          <source>Merriam-Webster</source>
          <access-date>2022-12-15</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.merriam-webster.com/dictionary/apathy">https://www.merriam-webster.com/dictionary/apathy</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>H-T</given-names>
            </name>
            <name name-style="western">
              <surname>Yoo</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Virtual reality sickness: a review of causes and measurements</article-title>
          <source>Int J Hum Comput Interact</source>
          <year>2020</year>
          <month>07</month>
          <day>02</day>
          <volume>36</volume>
          <issue>17</issue>
          <fpage>1658</fpage>
          <lpage>82</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1080/10447318.2020.1778351"/>
          </comment>
          <pub-id pub-id-type="doi">10.1080/10447318.2020.1778351</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Manera</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Chapoulie</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Bourgeois</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Guerchouche</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>David</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Ondrej</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Drettakis</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Robert</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>A feasibility study with image-based rendered virtual reality in patients with mild cognitive impairment and dementia</article-title>
          <source>PLoS One</source>
          <year>2016</year>
          <volume>11</volume>
          <issue>3</issue>
          <fpage>e0151487</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0151487"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0151487</pub-id>
          <pub-id pub-id-type="medline">26990298</pub-id>
          <pub-id pub-id-type="pii">PONE-D-15-34908</pub-id>
          <pub-id pub-id-type="pmcid">PMC4798753</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
