<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Serious Games</journal-id><journal-id journal-id-type="publisher-id">games</journal-id><journal-id journal-id-type="index">15</journal-id><journal-title>JMIR Serious Games</journal-title><abbrev-journal-title>JMIR Serious Games</abbrev-journal-title><issn pub-type="epub">2291-9279</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v12i1e55333</article-id><article-id pub-id-type="doi">10.2196/55333</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>Interactive Serious Game to Teach Basic Life Support Among Schoolchildren in Brazil: Design and Rationale</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Flato</surname><given-names>Uri Adrian Prync</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Beffa dos Santos</surname><given-names>Emilio Jos&#x00E9;</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bispo Diaz T Martins</surname><given-names>Isabella</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Rossignoli</surname><given-names>Vinicius Gazin</given-names></name><degrees>BM</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Dias Midega</surname><given-names>Thais</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kallas-Silva</surname><given-names>Lucas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Ferreira Mendes de Oliveira</surname><given-names>Ricardo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>do Socorro Lima Figueiredo Flato</surname><given-names>Adriana</given-names></name><degrees>BMS, MSc</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Vicente Guimar&#x00E3;es</surname><given-names>Mario</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Penna Guimar&#x00E3;es</surname><given-names>H&#x00E9;lio</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><institution>Hospital Israelita Albert Einstein</institution>, <addr-line>Albert Einstein 626, 513</addr-line><addr-line>S&#x00E3;o Paulo</addr-line>, <country>Brazil</country></aff><aff id="aff2"><institution>Faculdade Israelita de Ci&#x00EA;ncias em Sa&#x00FA;de Albert Einstein</institution>, <addr-line>S&#x00E3;o Paulo</addr-line>, <country>Brazil</country></aff><aff id="aff3"><institution>Internal Medicine Department, Universidade de Mar&#x00ED;lia</institution>, <addr-line>Mar&#x00ED;lia</addr-line>, <country>Brazil</country></aff><aff id="aff4"><institution>Instituto Sanare</institution>, <addr-line>S&#x00E3;o Paulo</addr-line>, <country>Brazil</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Leung</surname><given-names>Tiffany</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Straand</surname><given-names>Ingjerd</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Cavalcante</surname><given-names>Nilton</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Beninca</surname><given-names>Vitor</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Uri Adrian Prync Flato, MD, PhD, Hospital Israelita Albert Einstein, Albert Einstein 626, 513, S&#x00E3;o Paulo, 05653120, Brazil, 55 11975858889; <email>uriflato@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>9</day><month>10</month><year>2024</year></pub-date><volume>12</volume><elocation-id>e55333</elocation-id><history><date date-type="received"><day>09</day><month>12</month><year>2023</year></date><date date-type="rev-recd"><day>14</day><month>05</month><year>2024</year></date><date date-type="accepted"><day>12</day><month>07</month><year>2024</year></date></history><copyright-statement>&#x00A9; Uri Adrian Prync Flato, Emilio Jos&#x00E9; Beffa dos Santos, Isabella Bispo Diaz T Martins, Vinicius Gazin Rossignoli, Thais Dias Midega, Lucas Kallas-Silva, Ricardo Ferreira Mendes de Oliveira, Adriana do Socorro Lima Figueiredo Flato, Mario Vicente Guimar&#x00E3;es, H&#x00E9;lio Penna Guimar&#x00E3;es. Originally published in JMIR Serious Games (<ext-link ext-link-type="uri" xlink:href="https://games.jmir.org">https://games.jmir.org</ext-link>), 9.10.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Serious Games, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://games.jmir.org">https://games.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://games.jmir.org/2024/1/e55333"/><kwd-group><kwd>cardiopulmonary resuscitation</kwd><kwd>basic life support</kwd><kwd>serious game</kwd><kwd>CPR training</kwd><kwd>usability</kwd><kwd>cardiopulmonary</kwd><kwd>emergency</kwd><kwd>life support</kwd><kwd>CPR</kwd><kwd>training</kwd><kwd>education</kwd><kwd>game</kwd><kwd>gaming</kwd><kwd>educational</kwd><kwd>resuscitation</kwd><kwd>survey</kwd><kwd>satisfaction</kwd><kwd>SUS</kwd><kwd>user experience</kwd><kwd>System Usability Scale</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Cardiovascular diseases are among the leading causes of death and morbidity worldwide [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. Cardiopulmonary resuscitation (CPR) and early defibrillation increase survival chances [<xref ref-type="bibr" rid="ref3">3</xref>]. Serious games (SGs) are tools used to enhance the learning process through entertainment. Current strategies focus on teaching CPR to the community and schoolchildren [<xref ref-type="bibr" rid="ref4">4</xref>].</p><p>While other games exist for teaching basic life support (BLS), no studies have validated these for children in low- to middle-income settings. The SG Children Save Hearts teaches the 5 resuscitation steps per International Liaison Committee on Resuscitation (ILCOR) guidelines. Before use in schools, it requires a formal usability assessment by game developers and health care professionals to ensure ease of use, learning, and interaction.</p><p>The primary objective was to evaluate the usability of the SG Children Save Hearts among health care and IT professionals using the System Usability Scale (SUS) [<xref ref-type="bibr" rid="ref5">5</xref>], a validated usability assessment tool.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Ethical Considerations</title><p>The study protocol was approved by the ethics committee of the University of Mar&#x00ED;lia, Brazil (CAAE: 57160121400005496). All participants signed an informed consent form.</p></sec><sec id="s2-2"><title>Study Design</title><p>We used a nonprobabilistic casual sample to include IT and health care professionals. The usability test was conducted in August 2022 in the university&#x2019;s IT department after a 10-minute lecture on the SG&#x2019;s purpose. Children Save Hearts was developed on the Microsoft Smile Game Builder platform and implemented on Microsoft Windows (versions 7 to 11), targeting schoolchildren aged 7 to 17 years. The script and storytelling are based on the ILCOR 2020 guidelines. The game uses a joystick and simple commands to simplify the user experience (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). The design and testing process is illustrated in <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Design of a serious game for teaching cardiopulmonary resuscitation among schoolchildren. BLS: basic life support; MVP: minimum viable product; SAMU: Servi&#x00E7;o de Atendimento M&#x00F3;vel de Urg&#x00EA;ncia; SUS: System Usability Scale.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="games_v12i1e55333_fig01.png"/></fig><p>After completing the SG, participants answered a 10-question survey on its usability using a Likert-type scale. The final grade was converted to a 0 to 100 scale (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). A grade above 70 was considered acceptable to proceed to a minimum viable product. A sample size of 17 users was required, based on a 10% estimated probability of encountering an interface error, to identify 85% of the problems.</p></sec><sec id="s2-3"><title>Statistical Analysis</title><p>Categorical variables are presented as absolute and relative frequencies. Continuous variables are presented as medians with IQRs. Normality was assessed with the Shapiro-Wilk test. Comparisons were made between IT and health care professionals. Continuous variables were compared using an independent 2-tailed <italic>t</italic> test (for normal distributions) or the Mann-Whitney <italic>U</italic> test (for nonnormal distributions). All analyses were performed using R (version 4.1.0; R Foundation for Statistical Computing).</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>Children Save Hearts was used by 17 volunteers with a median age of 22 (IQR 20&#x2010;26) years; 8 (47%) were male. Regarding professional training, 8 (47%) held a bachelor&#x2019;s degree in IT and 9 (53%) were health care professionals. All participants played the game and answered the questionnaire. The median SUS score was 75 (IQR 72.5&#x2010;87.5; <xref ref-type="table" rid="table1">Table 1</xref>). Questions 2 and 4 had the lowest median scores, and questions 7 and 9 had the highest. Health care professionals gave higher grades to all 5 domains when compared to IT professionals. The average time spent in the game was 3.2 (SD 0.4) minutes.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Participant characteristics and System Usability Scale (SUS) scores by profession.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom"/><td align="left" valign="bottom">All (N=17)</td><td align="left" valign="bottom">IT professionals (n=8)</td><td align="left" valign="bottom">HCPs<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> (n=9)</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top"><bold>Participant characteristics</bold></td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Age (years), median (IQR)</td><td align="left" valign="top">22.00 (20.00-26.00)</td><td align="left" valign="top">21.00 (18.75-22.75)</td><td align="left" valign="top">24.00 (22.00-27.00)</td><td align="left" valign="top">.07<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Male sex, n (%)</td><td align="left" valign="top">8 (47)</td><td align="left" valign="top">4 (50)</td><td align="left" valign="top">4 (44)</td><td align="left" valign="top">&#x003E;.99<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td></tr><tr><td align="left" valign="top"><bold>SUS scores, median (IQR)</bold></td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Question 1</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (2.00-3.25)</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">.08<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 2</td><td align="left" valign="top">2.00 (2.00-3.00)</td><td align="left" valign="top">2.00 (1.75-3.00)</td><td align="left" valign="top">3.00 (2.00-3.00)</td><td align="left" valign="top">.47<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 3</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">.36<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 4</td><td align="left" valign="top">2.00 (2.00-3.00)</td><td align="left" valign="top">2.00 (1.75-2.25)</td><td align="left" valign="top">2.00 (2.00-3.00)</td><td align="left" valign="top">.61<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 5</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (3.00-3.00)</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">.07<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 6</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (2.00-3.25)</td><td align="left" valign="top">4.00 (4.00-4.00)</td><td align="left" valign="top">.002<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 7</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (3.00-3.00)</td><td align="left" valign="top">4.00 (4.00-4.00)</td><td align="left" valign="top">.009<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 8</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (2.75-3.25)</td><td align="left" valign="top">4.00 (4.00-4.00)</td><td align="left" valign="top">.02<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 9</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (3.00-3.25)</td><td align="left" valign="top">4.00 (4.00-4.00)</td><td align="left" valign="top">.03<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Question 10</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">3.50 (3.00-4.00)</td><td align="left" valign="top">3.00 (3.00-4.00)</td><td align="left" valign="top">.68<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top"><bold>Analysis, median (IQR)</bold></td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top">&#x2003;Total score</td><td align="left" valign="top">30.00 (29.00-35.00)</td><td align="left" valign="top">27.50 (25.50-30.50)</td><td align="left" valign="top">34.00 (30.00-35.00)</td><td align="left" valign="top">.05<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;SUS grade</td><td align="left" valign="top">75.00 (72.50-87.50)</td><td align="left" valign="top">68.75 (63.75-76.25)</td><td align="left" valign="top">85.00 (75.00-87.50)</td><td align="left" valign="top">.05<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Score for ease of learning domain (Q3, Q4, Q7, Q10)</td><td align="left" valign="top">3.25 (2.75-3.25)</td><td align="left" valign="top">3.00 (2.50-3.25)</td><td align="left" valign="top">3.25 (2.75-3.50)</td><td align="left" valign="top">.54<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Score for efficiency domain (Q5, Q6, Q8)</td><td align="left" valign="top">3.67 (3.00-4.00)</td><td align="left" valign="top">3.00 (2.50-3.17)</td><td align="left" valign="top">4.00 (3.67-4.00)</td><td align="left" valign="top">.02<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Score for ease of memorization domain (Q2)</td><td align="left" valign="top">2.00 (2.00-3.00)</td><td align="left" valign="top">2.00 (1.75-3.00)</td><td align="left" valign="top">3.00 (2.00-3.00)</td><td align="left" valign="top">.47<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Score for minimization of errors domain (Q6)</td><td align="left" valign="top">4.00 (3.00-4.00)</td><td align="left" valign="top">3.00 (2.00-3.25)</td><td align="left" valign="top">4.00 (4.00-4.00)</td><td align="left" valign="top">.002<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">&#x2003;Score for satisfaction domain (Q1, Q4, Q9)</td><td align="left" valign="top">2.67 (2.67-3.33)</td><td align="left" valign="top">2.67 (2.33-2.83)</td><td align="left" valign="top">3.33 (2.67-3.67)</td><td align="left" valign="top">.08<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>HCP: health care professional.</p></fn><fn id="table1fn2"><p><sup>b</sup>Mann-Whitney <italic>U</italic> test.</p></fn><fn id="table1fn3"><p><sup>c</sup>Fisher test.</p></fn><fn id="table1fn4"><p><sup>d</sup>2-sample Student <italic>t</italic> test.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>We developed an SG, Children Save Hearts, to teach BLS to schoolchildren. When tested on 17 IT and health care professionals, it achieved an overall mean SUS score of 75, suitable for implementation.</p><p>Novel technologies like virtual reality (VR) have been successfully used in Europe to teach CPR to schoolchildren [<xref ref-type="bibr" rid="ref6">6</xref>]. However, transferring this technology to limited-income countries faces challenges, such as language barriers, VR device acquisition, cultural context, and technical support. Previous SGs for teaching CPR were developed and tested in high-income countries [<xref ref-type="bibr" rid="ref7">7</xref>]. Educational strategies for teaching CPR in limited-income countries have focused on health care professionals and students [<xref ref-type="bibr" rid="ref8">8</xref>], not schoolchildren, highlighting a significant gap in the literature. This is the first SG developed in Brazil in Portuguese for schoolchildren.</p><p>Our study has some limitations. First, we had a small sample size due to insufficient data to calculate sample size in usability tests and financial constraints in contracting a software house. Continuous usability monitoring with larger sample sizes is needed to maintain external validation. Further studies should target schoolchildren to assess the effectiveness of teaching BLS in schools and explore user experiences to gain insights into how users feel about SGs.</p><p>Active teaching methods are crucial to improving survival rates and translating accessible knowledge into practice. Programs like Kids Save Lives [<xref ref-type="bibr" rid="ref9">9</xref>] and World Restart a Heart Day [<xref ref-type="bibr" rid="ref10">10</xref>] are teaching schoolchildren that CPR is vital. Despite some usability issues, the game is adequate for testing in schoolchildren.</p></sec></body><back><ack><p>We would like to thank the University of Mar&#x00ED;lia for the use of their facilities and resources. We also thank the participants for their time and dedication to our study.</p></ack><notes><sec><title>Data Availability</title><p>Due to the nature and design of this study, the raw data supporting our findings cannot be made publicly available. The data set contains detailed information that could compromise the privacy and confidentiality of the participants involved. Protecting participant confidentiality is a priority for us, and thus, in adherence to ethical considerations and participant consent agreements, we are unable to deposit our data in publicly accessible repositories or present it within the manuscript or supplementary files.</p></sec></notes><fn-group><fn fn-type="con"><p>UAPF contributed to conceptualization, methodology, software, validation, formal analysis, investigation, resources, data curation, writing (original draft), visualization, supervision, project administration, and funding acquisition. EJBdS contributed to conceptualization, validation, investigation, resources, writing (review and editing), visualization, and supervision. IBDTM contributed to software, validation, formal analysis, data curation, and writing (review and editing). VGR contributed to software, validation, investigation, data curation, and writing (review and editing). TDM contributed to methodology, validation, investigation, resources, data curation, writing (review and editing), and visualization. LK&#x2013;S contributed to writing (original draft, review, and editing) and supervision. RFMdO contributed to writing (original draft, review, and editing) and supervision. AdSLFF contributed to validation, formal analysis, investigation, resources, data curation, and writing (original draft). MVG contributed to methodology, software, validation, investigation, and writing (review and editing). HPG contributed to conceptualization, methodology, writing (original draft), and project administration.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">BLS</term><def><p>basic life support</p></def></def-item><def-item><term id="abb2">CPR</term><def><p>cardiopulmonary resuscitation</p></def></def-item><def-item><term id="abb3">ILCOR</term><def><p>International Liaison Committee on Resuscitation</p></def></def-item><def-item><term id="abb4">SG</term><def><p>serious game</p></def></def-item><def-item><term id="abb5">SUS</term><def><p>System Usability Scale</p></def></def-item><def-item><term id="abb6">VR</term><def><p>virtual reality</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name 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screenshots and setup.</p><media xlink:href="games_v12i1e55333_app1.pptx" xlink:title="PPTX File, 8718 KB"/></supplementary-material><supplementary-material id="app2"><label>Multimedia Appendix 2</label><p>System Usability Scale (SUS) questions and domains.</p><media xlink:href="games_v12i1e55333_app2.docx" xlink:title="DOCX File, 15 KB"/></supplementary-material></app-group></back></article>