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Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

We evaluate the number of clinics and number of patients, assuming that MPACT intervention reduces this frequency to 45% (n=240), 50% (n=300), and 55% (n=330). The power curves based on independent observations (no cluster effect) are shown in Figure 3. The graph shows that the recruitment of 30 clinics, with 20 patients per clinic, provides greater than 80% power to detect a difference in treatment interruption rates of 66% (control) and 55% (MPACT) with α=.05.

Beth E Meyerson, Alissa Davis, Richard A Crosby, Linnea B Linde-Krieger, Benjamin R Brady, Gregory A Carter, Arlene N Mahoney, David Frank, Janet Rothers, Zhanette Coffee, Elana Deuble, Jonathon Ebert, Mary F Jablonsky, Marlena Juarez, Barbara Lee, Heather M Lorenz, Michael D Pava, Kristen Tinsely, Sana Yousaf

JMIR Res Protoc 2025;14:e69829

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Given the anticipated overlap of these conditions, ≈20% (n=90) of women will have at least one maternal metabolic disease of interest (secondary outcome). Study data are collected using paper case report forms. These paper documents will be kept in a locked cupboard accessible only to local research staff. Patient information is collected and stored by the investigators in a confidential REDCap (Research Electronic Data Capture system; Vanderbilt University), with password protection and restricted access.

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

We reviewed 102 surgical pathology reports from 102 patients and excluded reports if they were from other organ sites (n=10), benign (n=2), cytopathology (n=5), or outside review (n=1). We included 84 reports for analysis. The study flowchart is shown in Figure 2. Flowchart of the study design and analysis. *The concordance rate was calculated as the total number of concordant answers/total number of answers for each of the 12 medical question answering (MQA).

Denise Lee, Akhil Vaid, Kartikeya M Menon, Robert Freeman, David S Matteson, Michael L Marin, Girish N Nadkarni

JMIR Form Res 2025;9:e64544

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

A much smaller number of studies (n=6) examined the utility of VR in chronic pain populations including intensive pain rehabilitation (n=1) [112], chronic burn dressing (n=1) [113], chronic musculoskeletal pain (n=1) [114], chronic cancer-related pain (n=2) [115,116], and chronic abdominal pain (n=1) [117]. See Figure 2 for the summary of pain populations included across the studies.

Courtney W Hess, Brittany N Rosenbloom, Giulia Mesaroli, Cristal Lopez, Nhat Ngo, Estreya Cohen, Carley Ouellette, Jeffrey I Gold, Deirdre Logan, Laura E Simons, Jennifer N Stinson

JMIR Pediatr Parent 2025;8:e63854

Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study

Perspectives of Adolescents and Young Adults With Inflammatory Bowel Disease on a Biopsychosocial Transition Intervention: Qualitative Interview Study

Participant characteristics (N=21). a Response categories based on participants’ language. b Multiple response options were possible. c IBDU: inflammatory bowel disease type unclassified. d UC: ulcerative colitis. e IBD: inflammatory bowel disease. Adolescents and young adults expressed a range of reflections on the meaning of the transition from pediatric to adult health care.

Brooke Allemang, Ashleigh Miatello, Mira Browne, Melanie Barwick, Pranshu Maini, Joshua Eszczuk, Chetan Pandit, Tandeep Sadhra, Laura Forhan, Natasha Bollegala, Nancy Fu, Kate Lee, Emily Dekker, Irina Nistor, Sara Ahola Kohut, Laurie Keefer, Anne Marie Griffiths, Thomas D Walters, Samantha Micsinszki, David R Mack, Sally Lawrence, Karen I Kroeker, Jacqueline de Guzman, Aalia Tausif, Claudia Tersigni, Samantha J Anthony, Eric I Benchimol

JMIR Pediatr Parent 2025;8:e64618

Extended Reality–Enhanced Mental Health Consultation Training: Quantitative Evaluation Study

Extended Reality–Enhanced Mental Health Consultation Training: Quantitative Evaluation Study

The CVR is calculated using the equation: where Ne represents the count of experts who have deemed the item as “essential,” and N denotes the total number of experts who have participated in the rating process. The CVR is a numerical value that quantifies the consensus among experts regarding the essential nature of the items under consideration. The critical value is a benchmark used to assess the appropriateness of items included in a content validity assessment.

Katherine Hiley, Zanib Bi-Mohammad, Luke Taylor, Rebecca Burgess-Dawson, Dominic Patterson, Devon Puttick-Whiteman, Christopher Gay, Janette Hiscoe, Chris Munsch, Sally Richardson, Mark Knowles-Lee, Celia Beecham, Neil Ralph, Arunangsu Chatterjee, Ryan Mathew, Faisal Mushtaq

JMIR Med Educ 2025;11:e64619

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

We have randomized 22 administrative wards in a 1:1 ratio and aim to enroll about 72 adolescent girls and young women from each (total N=about 1584) to receive either the Tu’Washindi intervention plus usual HIV prevention services, or usual HIV prevention services alone.

Sarah T Roberts, Alexandra M Minnis, Sue Napierala, Elizabeth T Montgomery, Lina Digolo, Mackenzie L Cottrell, Erica N Browne, Jacqueline Ndirangu, Joyce Boke, Kawango Agot

JMIR Res Protoc 2025;14:e55931

The AI Reviewer: Evaluating AI’s Role in Citation Screening for Streamlined Systematic Reviews

The AI Reviewer: Evaluating AI’s Role in Citation Screening for Streamlined Systematic Reviews

Hence, 121 citations (n=21, 17.4% included and n=100, 82.6% excluded) were tested against predefined eligibility criteria using Chat GPT 3.5 (version September 25, 2023), Chat GPT 4 (version September 25, 2023), Google Bard (version 1.15; released on September 2, 2023), Meta Llama 2 (70b parameters, version 2.1.1; released on October 10, 2023), and Claude AI 2 (version 1.3; released on July 11, 2023). We used descriptive statistics to evaluate sensitivity, specificity, and overall accuracy.

Jamie Ghossein, Brett N Hryciw, Tim Ramsay, Kwadwo Kyeremanteng

JMIR Form Res 2025;9:e58366

School-Partnered Collaborative Care (SPACE) for Pediatric Type 1 Diabetes: Development and Usability Study of a Virtual Intervention With Multisystem Community Partners

School-Partnered Collaborative Care (SPACE) for Pediatric Type 1 Diabetes: Development and Usability Study of a Virtual Intervention With Multisystem Community Partners

SPACEa design team community partner roles (n=17). a SPACE: school-partnered collaborative care. b Numbers add to more than 17 as partners could identify with more than one role. At the initial design meeting, participants generated 141 ideas for the SPACE redesign, of which 94 were unique. Partners assigned a numeric prioritization to ideas, which were then condensed to create a list of unique ideas (Multimedia Appendix 1).

Christine A March, Elissa Naame, Ingrid Libman, Chelsea N Proulx, Linda Siminerio, Elizabeth Miller, Aaron R Lyon

JMIR Diabetes 2025;10:e64096