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With the advent of antiretroviral therapy (ART) for HIV, people with HIV can now achieve near-normal life expectancies [1-4]. At the end of 2021, >50% of people with HIV in the United States were aged ≥50 years, primarily due to the effectiveness of ART [5]. However, the rates of viral suppression among the 1.2 million people with HIV in the United States continue to remain low, with current estimates of approximately 66% among people with HIV, despite the wider availability of ART [5].
JMIR Form Res 2025;9:e67997
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For example, mathematical models estimate that 50% of the MSM at substantial risk of HIV infection need to use Pr EP for it to have a significant impact on the hypothetical end of the HIV epidemic [9].
In addition to increasing Pr EP uptake, maintaining proper use and adherence is a major challenge in the context of combined HIV prevention. Inadequate use and discontinuation of Pr EP are complex phenomena that undermine its effectiveness as both an individual and collective strategy.
J Med Internet Res 2025;27:e67445
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Pre-exposure prophylaxis (Pr EP) describes a medication that is proven to be 99% effective when taken as prescribed to reduce the risk of getting HIV by taking a pill or injection among people who do not have HIV but may be vulnerable to being introduced to or “exposed” to it. The marginal use of Pr EP hinders progress toward decreasing the incidence of HIV cases among Black cisgender women.
JMIR Public Health Surveill 2025;11:e67367
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Reference 10: Web-Based STI/HIV Testing Services Available for Access in Australia: Systematic Searchhiv web-based sti/hiv testingHIV/AIDS/STI Prevention and Care
J Med Internet Res 2025;27:e63822
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In 2019, the US Department of Health and Human Services launched the Ending the HIV Epidemic initiative, establishing a goal to reduce new infections of HIV in the United States by 90% by the year 2030 [1]. Achieving this ambitious goal hinges on rapid linkage of newly diagnosed individuals to antiretroviral therapy (ART) and sustained HIV viral suppression to prevent transmission.
JMIR Form Res 2025;9:e59953
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Within the social cognitive theory model, the intervention will incorporate components such as HIV risk reduction education, treatment education including U=U, HIV prevention strategies like Pr EP, and gender affirmation within the context of HIV. Skill-building activities for HIV communication and disclosure risk assessment will be conducted in a confidential group setting.
JMIR Res Protoc 2025;14:e52121
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The Global AIDS report released by the Joint United Nations Programme on HIV/AIDS (UNAIDS) [1] estimated that there were 350,000 new HIV infections among people aged 15‐24 years in 2022. Young people accounted for 26% of HIV infections in the Asia-Pacific region in 2020; among them, 52% were men who have sex with men (MSM), making them a key population that requires focused attention for HIV prevention.
JMIR Public Health Surveill 2025;11:e66487
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HIV prevention with pre-exposure prophylaxis (Pr EP) can reduce the risk of HIV acquisition by 99% [4,5], but its public health impact depends on connecting populations at risk of HIV to Pr EP care and continuing care over time [6-9]. Uptake of Pr EP is increasing among White MSM on the east and west coasts but remains limited in minority groups in the South [10-12] where HIV incidence is the highest [13].
JMIR Res Protoc 2025;14:e64813
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In response to these inequities, the US federal agencies are working in a coordinated manner to end the HIV Epidemic with a mandate to focus on populations facing HIV inequities and geographic hot spots, with prioritization to increase utilization of effective biomedical prevention tools like HIV pre-exposure prophylaxis (Pr EP), that reduces HIV transmission with consistent use [4-7].
JMIR Res Protoc 2025;14:e58976
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This analysis builds on extant literature by assessing the strengths and limitations of fraud deterrence and detection procedures that were implemented in an incentivized, cross-sectional, online study about HIV prevention and sexual health with a convenience sample of Black cisgender women living in Texas, United States.
JMIR Form Res 2025;9:e59955
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