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Skip search results from other journals and go to results- 313 Journal of Medical Internet Research
- 249 JMIR Mental Health
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Depression is one of the most prevalent mental disorders [1] and severely impacts the quality of life and functioning of affected individuals [2]. Depression is also associated with an increased risk of cardiovascular disease [3] and mortality [4].
JMIR Form Res 2025;9:e65357
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In human-human therapeutic interactions, body language, tone, and other social cues are critical to conveying empathy and can influence therapeutic outcomes in individuals with depression [42-44]. Research with chatbots [13] and ECAs [45] has demonstrated that individuals experiencing depressive symptoms report high perceived virtual agent empathy and user-agent working alliance with levels mirroring that of CBT-based human interventions.
JMIR Ment Health 2025;12:e67381
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Mental health challenges among adolescents have become increasingly prevalent, with issues like anxiety, depression, and stress-related disorders affecting a significant portion of this population [1-4]. Adolescence is a critical developmental period marked by emotional, cognitive, and social changes, which can increase vulnerability to mental health disorders [5-7].
JMIR Pediatr Parent 2025;8:e67137
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Another study also indicated the potential of demographic features for predicting depression using machine learning algorithms; however, social media data were not used [17]. Most social media platforms include user profiles with demographic information that can be used for depression prediction [18]. Thus, assessing the role of demographics in depression prediction is vital.
J Med Internet Res 2025;27:e59002
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In addition, poor psychosocial functioning and emotional distress (eg, anxiety, depression, and social isolation) can persist well beyond active treatment [5-7]. These negative psychological factors, common among allo-SCT recipients [5,6], are associated with higher mortality rates and less favorable health outcomes in the first-year posttreatment [8-10], including greater rates of GVHD and infection, longer hospitalization stays, and higher readmission rates [11].
JMIR Form Res 2025;9:e65188
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Infant sleep problems further contribute to significant maternal sleep issues [30-32] and maternal mental health consequences, regardless of the mothers’ depression history [32-34]. Mothers who report poor infant sleep behavior have significantly more depressive symptoms than mothers who report good infant sleep [35-37]. There is some evidence that maternal sleep quality is a mediator of this relationship [35].
JMIR Res Protoc 2025;14:e66439
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Table 2 presents the prevalence of depression categorized by recruitment method and race and ethnicity among all participants (N=380). Of the participants, 115 (30.26%) had a history of depression, while 265 (69.74%) had no history of depression. Our findings showed a difference between the prevalence of depression and the recruitment methods (P=.03).
In the nonsocial media group (n=273, 71.84%), the prevalence rates of depression (n=74, 27.11%) varied by race and ethnicity.
JMIR Form Res 2025;9:e58916
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Adolescent depression and suicidality are part of a growing public health crisis that has been further exacerbated by the COVID-19 pandemic [1]. In 2022, 19.5% of US adolescents aged 12‐17 years experienced a major depressive episode and 13.4% reported having seriously considered suicide [2]. Pediatric societies recommend that pediatric primary care providers (PCPs) screen adolescents for both depression and suicidality [3-6].
JMIR Form Res 2025;9:e67624
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Perinatal depression, a condition common in pregnant women, is higher among adolescent mothers than older mothers [10,11] occurring during pregnancy and up to one year after childbirth. Untreated perinatal depression is a risk for negative health outcomes for mothers and their infants [12].
JMIR Form Res 2025;9:e42406
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Figure 3 shows a forest plot for the pooled results on depression. Depression was measured by 11 studies using the Hospital Anxiety and Depression Scale (HADS) [34,35,38,42], Beck Depression Inventory [24,36], Patient Health Questionnaire–9 [33,37,39,41], or the Depression, Anxiety, and Stress Scale (DASS) [31].
J Med Internet Res 2025;27:e57368
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