Published on in Vol 6 , No 4 (2018) :Oct-Dec

Preprints (earlier versions) of this paper are available at, first published .
Virtual Reality Clinical Research: Promises and Challenges

Virtual Reality Clinical Research: Promises and Challenges

Virtual Reality Clinical Research: Promises and Challenges


  1. Georgieva I, Georgiev G. Reconstructing Personal Stories in Virtual Reality as a Mechanism to Recover the Self. International Journal of Environmental Research and Public Health 2019;17(1):26 View
  2. Lindner P, Rozental A, Jurell A, Reuterskiöld L, Andersson G, Hamilton W, Miloff A, Carlbring P. Experiences of Gamified and Automated Virtual Reality Exposure Therapy for Spider Phobia: Qualitative Study. JMIR Serious Games 2020;8(2):e17807 View
  3. Garrett B, Tao G, Taverner T, Cordingley E, Sun C. Patients perceptions of virtual reality therapy in the management of chronic cancer pain. Heliyon 2020;6(5):e03916 View
  4. Persky S. A Virtual Home for the Virtual Clinical Trial. Journal of Medical Internet Research 2020;22(1):e15582 View
  5. Haisley K, Straw O, Müller D, Antiporda M, Zihni A, Reavis K, Bradley D, Dunst C. Feasibility of implementing a virtual reality program as an adjuvant tool for peri-operative pain control; Results of a randomized controlled trial in minimally invasive foregut surgery. Complementary Therapies in Medicine 2020;49:102356 View
  6. Schleider J, Mullarkey M, Weisz J. Virtual Reality and Web-Based Growth Mindset Interventions for Adolescent Depression: Protocol for a Three-Arm Randomized Trial. JMIR Research Protocols 2019;8(7):e13368 View
  7. Tabrizi M, Manshaee G, Ghamarani A, Rasti J. Comparison of the effectiveness of virtual reality with medication on the memory of attention deficit hyperactivity disorder students. International Archives of Health Sciences 2020;7(1):37 View
  8. Dermody G, Whitehead L, Wilson G, Glass C. The Role of Virtual Reality in Improving Health Outcomes for Community-Dwelling Older Adults: Systematic Review. Journal of Medical Internet Research 2020;22(6):e17331 View
  9. Rousseaux F, Bicego A, Ledoux D, Massion P, Nyssen A, Faymonville M, Laureys S, Vanhaudenhuyse A. <p>Hypnosis Associated with 3D Immersive Virtual Reality Technology in the Management of Pain: A Review of the Literature</p>. Journal of Pain Research 2020;Volume 13:1129 View
  10. Garrett B, Mallia E, Anthony J. Public perceptions of Internet‐based health scams, and factors that promote engagement with them. Health & Social Care in the Community 2019 View
  11. Patel P, Ivanov D, Bhatt S, Mastorakos G, Birckhead B, Khera N, Vittone J. Low-Cost Virtual Reality Headsets Reduce Perceived Pain in Healthy Adults: A Multicenter Randomized Crossover Trial. Games for Health Journal 2020;9(2):129 View
  12. Marvel J, Bagchi S, Zimmerman M, Antonishek B. Towards Effective Interface Designs for Collaborative HRI in Manufacturing. ACM Transactions on Human-Robot Interaction 2020;9(4):1 View
  13. Jenny C, Reuter C. Usability of Individualized Head-Related Transfer Functions in Virtual Reality: Empirical Study With Perceptual Attributes in Sagittal Plane Sound Localization. JMIR Serious Games 2020;8(3):e17576 View
  14. Sayma M, Tuijt R, Cooper C, Walters K, Heyn P. Are We There Yet? Immersive Virtual Reality to Improve Cognitive Function in Dementia and Mild Cognitive Impairment. The Gerontologist 2020;60(7):e502 View
  15. Moore N, Yoo S, Poronnik P, Brown M, Ahmadpour N. Exploring User Needs in the Development of a Virtual Reality–Based Advanced Life Support Training Platform: Exploratory Usability Study. JMIR Serious Games 2020;8(3):e20797 View
  16. Fowler C, Ballistrea L, Mazzone K, Martin A, Kaplan H, Kip K, Ralston K, Murphy J, Winkler S. Virtual Reality as a Therapy Adjunct for Fear of Movement in Veterans With Chronic Pain: Single-Arm Feasibility Study. JMIR Formative Research 2019;3(4):e11266 View
  17. Cortés-Pérez I, Nieto-Escamez F, Obrero-Gaitán E. Immersive Virtual Reality in Stroke Patients as a New Approach for Reducing Postural Disabilities and Falls Risk: A Case Series. Brain Sciences 2020;10(5):296 View
  18. Keshner E, Weiss P, Geifman D, Raban D. Tracking the evolution of virtual reality applications to rehabilitation as a field of study. Journal of NeuroEngineering and Rehabilitation 2019;16(1) View
  19. Vertemati M, Cassin S, Rizzetto F, Vanzulli A, Elli M, Sampogna G, Gallieni M. A Virtual Reality Environment to Visualize Three-Dimensional Patient-Specific Models by a Mobile Head-Mounted Display. Surgical Innovation 2019;26(3):359 View
  20. Wang L, Casto B, Luh J, Wang S. Virtual Reality-Based Education for Patients Undergoing Radiation Therapy. Journal of Cancer Education 2022;37(3):694 View
  21. Kenngott H, Pfeiffer M, Preukschas A, Bettscheider L, Wise P, Wagner M, Speidel S, Huber M, Nickel F, Mehrabi A, Müller-Stich B. IMHOTEP: cross-professional evaluation of a three-dimensional virtual reality system for interactive surgical operation planning, tumor board discussion and immersive training for complex liver surgery in a head-mounted display. Surgical Endoscopy 2022;36(1):126 View
  22. Mouatt B, Smith A, Mellow M, Parfitt G, Smith R, Stanton T. The Use of Virtual Reality to Influence Motivation, Affect, Enjoyment, and Engagement During Exercise: A Scoping Review. Frontiers in Virtual Reality 2020;1 View
  23. Tao G, Garrett B, Taverner T, Cordingley E, Sun C. Immersive virtual reality health games: a narrative review of game design. Journal of NeuroEngineering and Rehabilitation 2021;18(1) View
  24. Trost Z, France C, Anam M, Shum C. Virtual reality approaches to pain: toward a state of the science. Pain 2021;162(2):325 View
  25. Best P, McKenna A, Quinn P, Duffy M, Van Daele T. Can Virtual Reality Ever Be Implemented in Routine Clinical Settings? A Systematic Narrative Review of Clinical Procedures Contained Within Case Reports for the Treatment of PTSD. Frontiers in Virtual Reality 2020;1 View
  26. Rutkowska A, Rutkowski S, Szczepańska-Gieracha J. The use of total immersion in the rehabilitation process. Rehabilitacja Medyczna 2020;24(2):27 View
  27. Tran J, Fowler C, Delikat J, Kaplan H, Merzier M, Schlesinger M, Litzenberger S, Marszalek J, Scott S, Winkler S. Immersive Virtual Reality to Improve Outcomes in Veterans With Stroke: Protocol for a Single-Arm Pilot Study. JMIR Research Protocols 2021;10(5):e26133 View
  28. Pereira M, Prahm C, Kolbenschlag J, Oliveira E, Rodrigues N. Application of AR and VR in hand rehabilitation: A systematic review. Journal of Biomedical Informatics 2020;111:103584 View
  29. Keshner E, Lamontagne A. The Untapped Potential of Virtual Reality in Rehabilitation of Balance and Gait in Neurological Disorders. Frontiers in Virtual Reality 2021;2 View
  30. Nizamis K, Athanasiou A, Almpani S, Dimitrousis C, Astaras A. Converging Robotic Technologies in Targeted Neural Rehabilitation: A Review of Emerging Solutions and Challenges. Sensors 2021;21(6):2084 View
  31. Orr N, Yeo N, Dean S, White M, Garside R. “It Makes You Feel That You Are There”: Exploring the Acceptability of Virtual Reality Nature Environments for People with Memory Loss. Geriatrics 2021;6(1):27 View
  32. Kakoschke N, Page R, de Courten B, Verdejo-Garcia A, McCormack J. Brain training with the body in mind: Towards gamified approach-avoidance training using virtual reality. International Journal of Human-Computer Studies 2021;151:102626 View
  33. Lima Rebêlo F, de Souza Silva L, Doná F, Sales Barreto A, de Souza Siqueira Quintans J. Immersive virtual reality is effective in the rehabilitation of older adults with balance disorders: A randomized clinical trial. Experimental Gerontology 2021;149:111308 View
  34. Fu H, Garrett B, Tao G, Cordingley E, Ofoghi Z, Taverner T, Sun C, Cheung T. Virtual Reality–Guided Meditation for Chronic Pain in Patients With Cancer: Exploratory Analysis of Electroencephalograph Activity. JMIR Biomedical Engineering 2021;6(2):e26332 View
  35. Fonseca D, Cavalcanti J, Peña E, Valls V, Sanchez-Sepúlveda M, Moreira F, Navarro I, Redondo E. Mixed Assessment of Virtual Serious Games Applied in Architectural and Urban Design Education. Sensors 2021;21(9):3102 View
  36. Piech J, Czernicki K. Virtual Reality Rehabilitation and Exergames—Physical and Psychological Impact on Fall Prevention among the Elderly—A Literature Review. Applied Sciences 2021;11(9):4098 View
  37. Amorim P, Paulo J, Silva P, Peixoto P, Castelo-Branco M, Martins H. Machine Learning Applied to Low Back Pain Rehabilitation – A Systematic Review. International Journal of Digital Health 2021;1(1):10 View
  38. Akin B, Yilmaz Kocak M, Küçükaydın Z, Güzel K. The Effect of Showing Images of the Foetus with the Virtual Reality Glass During Labour Process on Labour Pain, Birth Perception and Anxiety. Journal of Clinical Nursing 2021;30(15-16):2301 View
  39. Salisbury J. Using Medical Device Standards for Design and Risk Management of Immersive Virtual Reality for At-Home Therapy and Remote Patient Monitoring. JMIR Biomedical Engineering 2021;6(2):e26942 View
  40. Zhai K, Dilawar A, Yousef M, Holroyd S, El-Hammali H, Abdelmonem M. Virtual Reality Therapy for Depression and Mood in Long-Term Care Facilities. Geriatrics 2021;6(2):58 View
  41. Krish G, Immerman I, Kinjo S. Virtual reality may reduce anxiety and enhance surgical experience during wide-awake local anaesthesia no tourniquet surgery: A report of two cases. Journal of Perioperative Practice 2022;32(6):136 View
  42. Mohamad U, Ahmad M, Benferdia Y, Shapi'i A, Bajuri M. An Overview of Ontologies in Virtual Reality-Based Training for Healthcare Domain. Frontiers in Medicine 2021;8 View
  43. Tsamitros N, Sebold M, Gutwinski S, Beck A. Virtual Reality-Based Treatment Approaches in the Field of Substance Use Disorders. Current Addiction Reports 2021;8(3):399 View
  44. Rimer E, Husby L, Solem S. Virtual Reality Exposure Therapy for Fear of Heights: Clinicians’ Attitudes Become More Positive After Trying VRET. Frontiers in Psychology 2021;12 View
  45. Ong T, Wilczewski H, Paige S, Soni H, Welch B, Bunnell B. Extended Reality for Enhanced Telehealth During and Beyond COVID-19: Viewpoint. JMIR Serious Games 2021;9(3):e26520 View
  46. Brassel S, Power E, Campbell A, Brunner M, Togher L. Recommendations for the Design and Implementation of Virtual Reality for Acquired Brain Injury Rehabilitation: Systematic Review. Journal of Medical Internet Research 2021;23(7):e26344 View
  47. Son H, Ross A, Mendoza-Tirado E, Lee L. Virtual Reality in Clinical Practice and Research: Viewpoint on Novel Applications for Nursing. JMIR Nursing 2022;5(1):e34036 View
  48. Kamm C, Blättler R, Kueng R, Vanbellingen T. Feasibility and usability of a new home-based immersive virtual reality headset-based dexterity training in multiple sclerosis. Multiple Sclerosis and Related Disorders 2023;71:104525 View
  49. Estrella‐Juarez F, Requena‐Mullor M, Garcia‐Gonzalez J, Lopez‐Villen A, Alarcon‐Rodriguez R. Effect of Virtual Reality and Music Therapy on the Physiologic Parameters of Pregnant Women and Fetuses and on Anxiety Levels: A Randomized Controlled Trial. Journal of Midwifery & Women's Health 2023;68(1):35 View
  50. Khatkar H, Ferro A, Kotecha S, Prokopenko M, Evans A, Kyriakides J, Botterill J, Sangha M, See A, Kerstein R. Assessing the attitude of surgical trainees towards virtual reality simulation: A national cross-sectional questionnaire study. Scottish Medical Journal 2022;67(3):87 View
  51. Cheng X, Zhang S, Fu S, Liu W, Guan C, Mou J, Ye Q, Huang C. Exploring the metaverse in the digital economy: an overview and research framework. Journal of Electronic Business & Digital Economics 2022;1(1/2):206 View
  52. Schneider V, Bush N, Vitus D, Carpenter R, Robinson M, Boissoneault J. A virtual reality platform for the measurement of drinking topography. Drug and Alcohol Dependence 2022;231:109246 View
  53. Johnston S, Strong G, Knowles S. Virtual reality: the future or a COVID-era plaster?. Journal of Paramedic Practice 2022;14(12):504 View
  54. Moore N, Ahmadpour N, Brown M, Poronnik P, Davids J. Designing Virtual Reality–Based Conversational Agents to Train Clinicians in Verbal De-escalation Skills: Exploratory Usability Study. JMIR Serious Games 2022;10(3):e38669 View
  55. Sadowski I, Khoury B. Nature-based mindfulness-compassion programs using virtual reality for older adults: A narrative literature review. Frontiers in Virtual Reality 2022;3 View
  56. Brown P, Powell W, Dansey N, Al-Abbadey M, Stevens B, Powell V. Virtual Reality as a Pain Distraction Modality for Experimentally Induced Pain in a Chronic Pain Population: An Exploratory Study. Cyberpsychology, Behavior, and Social Networking 2022;25(1):66 View
  57. Baheri Islami S, Wesolowski M, Revell W, Chen X. Virtual Reality Visualization of CFD Simulated Blood Flow in Cerebral Aneurysms Treated with Flow Diverter Stents. Applied Sciences 2021;11(17):8082 View
  58. Durrani S, Onyedimma C, Jarrah R, Bhatti A, Nathani K, Bhandarkar A, Mualem W, Ghaith A, Zamanian C, Michalopoulos G, Alexander A, Jean W, Bydon M. The Virtual Vision of Neurosurgery: How Augmented Reality and Virtual Reality are Transforming the Neurosurgical Operating Room. World Neurosurgery 2022;168:190 View
  59. Zaharuddin F, Ibrahim N, Yusof A. A Conceptual Framework for Designing Virtual Environments for Stress Therapy. Applied Sciences 2022;12(19):9973 View
  60. Doré B, Gaudreault A, Everard G, Ayena J, Abboud A, Robitaille N, Batcho C. Acceptability, Feasibility, and Effectiveness of Immersive Virtual Technologies to Promote Exercise in Older Adults: A Systematic Review and Meta-Analysis. Sensors 2023;23(5):2506 View
  61. Hu J, Browne J, Arnold M, Robinson A, Heacock M, Ku R, Mologne M, Baum G, Ikemiya K, Neufeld E, Dolezal B. Physiological and Metabolic Requirements, and User-Perceived Exertion of Immersive Virtual Reality Exergaming Incorporating an Adaptive Cable Resistance System: An Exploratory Study. Games for Health Journal 2021 View
  62. Lopes R, Barroso B, Deusdado L, Novo A, Guimarães M, Teixeira J, Leitão P. Digital Technologies for Innovative Mental Health Rehabilitation. Electronics 2021;10(18):2260 View
  63. Bui J, Luauté J, Farnè A. Enhancing Upper Limb Rehabilitation of Stroke Patients With Virtual Reality: A Mini Review. Frontiers in Virtual Reality 2021;2 View
  64. Wu X, Du J, Jiang H, Zhao M. Application of Digital Medicine in Addiction. Journal of Shanghai Jiaotong University (Science) 2022;27(2):144 View
  65. Villemin C, Abel F, Dispersyn G, Cotty-Eslous M, Marchand S. La réalité virtuelle comme antidouleur : une revue systématique de la littérature. Douleur et Analgésie 2021;34(3):163 View
  66. Goldsmith D, Flash S, Holdnack J, Brennan P. Designing Immersive Virtual Reality Environments for Supporting Patients at Home. CIN: Computers, Informatics, Nursing 2023;41(3):142 View
  67. Ong C, Tan M, Lam M, Koh V. Applications of Extended Reality in Ophthalmology: Systematic Review. Journal of Medical Internet Research 2021;23(8):e24152 View
  68. Muñoz E, Fabregat R, Bacca-Acosta J, Duque-Méndez N, Avila-Garzon C. Augmented Reality, Virtual Reality, and Game Technologies in Ophthalmology Training. Information 2022;13(5):222 View
  69. Asada C, Tsutsumi K, Tamura Y, Hara N, Omori W, Otsuka Y, Sato K. Electrical Muscle Stimulation to Develop and Implement Menstrual Simulator System. Journal of Robotics and Mechatronics 2021;33(5):1051 View

Books/Policy Documents

  1. Hudlicka E. Augmented Cognition. Human Cognition and Behavior. View
  2. Burlaga B, Osińska M, Gembara P, Smółkowska E, Merda T, Gorzkowski M. Innovations in Biomedical Engineering. View
  3. Bucea-Manea-Ţoniş R, Gurgu E, Martins O, Simion V. Consumer Happiness: Multiple Perspectives. View
  4. Schmidt M, Newbutt N. Design, User Experience, and Usability: Design for Diversity, Well-being, and Social Development. View
  5. Zhao F, Sochacki D, Witenko J, Kogan R. HCI International 2022 – Late Breaking Papers: HCI for Health, Well-being, Universal Access and Healthy Aging. View
  6. Li R, Belter M, Platt-Young Z, Lukosch H. Handbook of Research on Promoting Economic and Social Development Through Serious Games. View
  7. Ebrahimi E, Hajj D, Jarrett M, Ferrell A, Haddad L, Chelala M. Virtual, Augmented and Mixed Reality: Design and Development. View
  8. Issa T, Isaias P. Sustainable Design. View